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A partially handicapped man named Karl is released from a mental hospital, about 20 years after murdering his mother and another person. Karl is often questioned if he will ever kill again, and he shrugs in response saying there is no reason to. Now out of the mental institution, Karl settles in his old, small hometown, occupying himself by fixing motors. After meeting a young boy named Frank, who befriends him, Karl is invited to stay at Frank's house with his mother Linda, who views Karl as a strange but kind and generous man. However, Linda's abusive boyfriend, Doyle, sees things differently in the way rules ought to be run- normally insulting Linda's homosexual friend Vaughan as well as Karl's disabilities, and having wild parties with his friends. As Karl's relationship with Frank grows, he is watchful of Doyle's cruel actions.

The intersecting life stories of Daniel Plainview and Eli Sunday in early twentieth century California is presented. Miner turn oilman Daniel Plainview is a driven man who will do whatever it takes to achieve his goals. He works hard but he also takes advantage of those around him at their expense if need be. His business partner is his son H.W., who in reality he "acquired" when H.W.'s biological single father, who worked on one of Daniel's rigs, got killed in a workplace accident. Daniel is deeply protective of H.W. if only for what H.W. brings to the partnership. Eli Sunday is one in a pair of twins, whose family farm Daniel purchases for the major oil deposit located on it. Eli, the local preacher and a self-proclaimed faith healer, wants the money from the sale of the property to finance his own church. The lives of the two competitive men often clash as Daniel pumps oil off the property and tries to acquire all the surrounding land at bargain prices to be able to build a pipeline to the coast, and as Eli tries to build his own religious empire.

Enid and Rebecca after they finish the high school. Both have problems relating to people and they spend their time hanging around and bothering creeps. When they meet Seymour who is a social outsider who loves to collect old 78 records, Enid's life will change forever.

In 1986, In Brooklyn, New York, the dysfunctional family of pseudo intellectuals composed by the university professor Bernard and the prominent writer Joan split. Bernard is a selfish, cheap and jealous decadent writer that rationalizes every attitude in his family and life and does not accept "philistines" - people that do not read books or watch movies, while the unfaithful Joan is growing as a writer and has no problems with "philistines". Their sons, the teenager Walt and the boy Frank, feel the separation and take side: Walt stays with Bernard, and Frank with Joan, and both are affected with abnormal behaviors. Frank drinks booze and smears with sperm the books in the library and a locker in the dress room of his school. The messed-up and insecure Walt uses Roger Water's song "Hey You" in a festival as if it was of his own, and breaks up with his girlfriend Sophie. Meanwhile Joan has an affair with Frank's tennis teacher Ivan and Bernard with his student Lili.

A woman's life is derailed en route to a potentially lucrative summer job. When her car breaks down, and her dog is taken to the pound, the thin fabric of her financial situation comes apart, and she is led through a series of increasingly dire economic decisions.

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During the 1973 Thanksgiving weekend, the Hoods are - relationship-wise, skidding out-of-control, isolated from each other; Benjamin reels from drink-to-drink, His wife, Elena's losing patience with Ben's incessant lies. Home for the holidays, their son, Paul, heads into Manhattan, in search of a rich girl from his prep school. Wendy, the teenage daughter, roams the neighborhood, exploring the liquor and lingerie of her friends' parents, looking for something - anything - new. Then, an ice storm hits, and their problems seem inconsequential, and nothing will ever be the same.

Theater director Caden Cotard is mounting a new play. Fresh off of a successful production of Death of a Salesman, he has traded in the suburban blue-hairs and regional theater of Schenectady for the cultured audiences and bright footlights of Broadway. Armed with a MacArthur grant and determined to create a piece of brutal realism and honesty, something into which he can put his whole self, he gathers an ensemble cast into a warehouse in Manhattan's theater district. He directs them in a celebration of the mundane, instructing each to live out their constructed lives in a small mock-up of the city outside. As the city inside the warehouse grows, Caden's own life veers wildly off the tracks. The shadow of his ex-wife Adele, a celebrated painter who left him years ago for Germany's art scene, sneers at him from every corner. Somewhere in Berlin, his daughter Olive is growing up under the questionable guidance of Adele's friend, Maria. He's helplessly driving his marriage to actress Claire into the ground. Sammy Barnathan, the actor Caden has hired to play himself within the play, is a bit too perfect for the part, and is making it difficult for Caden to revive his relationship with the alluringly candid Hazel. Meanwhile, his therapist, Madeline Gravis, is better at plugging her best-seller than she is at counselling him. His second daughter, Ariel, is disabled. And a mysterious condition is systematically shutting down each of his autonomic functions, one by one. As the years rapidly pass, Caden buries himself deeper into his masterpiece. Populating the cast and crew with doppelgangers, he steadily blurs the line between the world of the play and that of his own deteriorating reality. As he pushes the limits of his relationships, both personally and professionally, a change in creative direction arrives in Millicent Weems, a celebrated theater actress who may offer Caden the break he needs.

Middle-aged American movie star Bob Harris is in Tokyo to film a personal endorsement Suntory whiskey ad solely for the Japanese market. He is past his movie star prime, but his name and image still have enough cachet for him to have gotten this lucrative $2 million job. He has an unsatisfying home life where his wife Lydia follows him wherever he goes - in the form of messages and faxes - for him to deal with the minutiae of their everyday lives, while she stays at home to look after their kids. Staying at the same upscale hotel is fellow American, twenty-something recent Yale Philosophy graduate Charlotte, her husband John, an entertainment still photographer, who is on assignment in Japan. As such, she is largely left to her own devices in the city, especially when his job takes him out of Tokyo. Both Bob and Charlotte are feeling lost by their current situations, which are not helped by the cultural barriers they feel in Tokyo, those cultural barriers extending far beyond just not knowing the language. After a few chance encounters in the hotel, they end up spending much of their time hanging out together, each helping the other deal with their feelings of loss in their current lives. The friendship that develops between the two, which is not always a bumpy-free one, may be just for this specific place and time, but it may also have long lasting implications.

Hannah, Holly, and Lee are adult sisters from a show business family, their boozy actress mother who still believes she's an ingénue that can attract any man she wants, despite still being married to the girls' father, Evan. Hannah, on her second marriage to a man named Elliot, a financial advisor, is the success of the family, taking a break from her acting career to raise her children. Everyone turns to her for advice, while she never talks to others about what she needs or feels. Her first husband, Mickey, is a comedy show writer and hypochondriac, who is going through a crisis as he mistakenly believes he will die soon without a clear belief, as a non-practicing Jew, of what will happen to him in the afterlife. Single Holly is the insecure flaky sister, a struggling and thus continually unemployed actress, who has just started a catering business with her actress friend April, in order to do something constructive with her life. In her own security, Hannah even set up Holly and Mickey together following her own break-up with Mickey, Holly and Mickey's sole date which arguably was the worst night in both their lives. Holly turns to Hannah for everything in her life, including money, despite feeling Hannah overly judgmental about her failures. It's during a catering job that Holly and April meet David, an architect, who seems interested in both of them. Holly's insecurities may threaten her potential relationship with David and friendship with April. Lee, who collects unemployment, is metaphorically the family's piece of clay waiting for the right artist to mold her. She has long lived with artist Frederick, who has contempt for everyone except her, and as such relies on her for whatever his connection to the outside world. This already complex collective becomes even more complex when Elliot contemplates telling Lee that he has fallen in love with her. His attraction to her is as much feeling unneeded by Hannah, who he does not want to hurt regardless of what he decides to do with respect to Lee.

The resolutely single Don Johnston has just been dumped by his latest lover, Sherry. Don resigns himself to being alone yet again and left to his own devices. Instead, he is compelled to reflect on his past when he receives by mail a mysterious pink letter. It is from an anonymous former lover and informs him that he has a 19-year-old son who may now be looking for his father. Don is urged to investigate this "mystery" by his closest friend and neighbor, Winston, an amateur sleuth and family man. Hesitant to travel at all, Don nonetheless embarks on a cross-country trek in search of clues from four former flames. Unannounced visits to each of these unique women hold new surprises for Don as he haphazardly confronts both his past and, consequently, his present.

Warren Schmidt (Jack Nicholson) has led a safe, predictable life working in the insurance industry in Omaha, Nebraska for many years, yet now faces retirement. At the same time, he is forced to take a hard look at his wife, his life, and his relationship with his estranged daughter. An often hilarious series of events follow as Schmidt embarks on an unpredictable RV journey to attend his daughter's wedding in Denver, Colorado.

A woman breaks up with her boyfriend, he thinks it's because he's fat. A man is unable to tell her next door neighbor he finds her sexually attractive. An old couple wants to split up, but they don't want to get a divorce. A therapist masturbates to teen magazines. An 11 year old kid is insecure about the fact that he hasn't cum yet. Office workers try to recall the face of a coworker who recently died. A woman is sure she has everything she could ever want. The lives of these individuals intertwine as they go about their lives in their own unique ways, engaging in acts society as a whole might find disturbing in a desperate search for human connection.

Adult film director Jack Horner is always on the lookout for new talent and it's only by chance that he meets Eddie Adams who is working as a busboy in a restaurant. Eddie is young, good looking and plenty of libido to spare. Using the screen name Dirk Diggler, he quickly rises to the top of his industry winning awards year after year. Drugs and ego however come between Dirk and those around him and he soon finds that fame is fleeting.

24 hours in L.A.; it's raining cats and dogs. Two parallel and intercut stories dramatize men about to die: both are estranged from a grown child, both want to make contact, and neither child wants anything to do with dad. Earl Partridge's son is a charismatic misogynist; Jimmy Gator's daughter is a cokehead and waif. A mild and caring nurse intercedes for Earl, reaching the son; a prayerful and upright beat cop meets the daughter, is attracted to her, and leads her toward a new calm. Meanwhile, guilt consumes Earl's young wife, while two whiz kids, one grown and a loser and the other young and pressured, face their situations. The weather, too, is quirky.

A man wanders out of the desert after a four year absence. His brother finds him, and together they return to L.A. to reunite the man with his young son. Soon after, he and the boy set out to locate the mother of the child, who left shortly after the man disappeared.

In Albuquerque, Sheryl Hoover brings her suicidal brother Frank to the breast of her dysfunctional and emotionally bankrupted family. Frank is homosexual, an expert in Proust. He tried to commit suicide when he was rejected by his boyfriend and his great competitor became renowned and recognized as number one in the field of Proust. Sheryl's husband Richard is unsuccessfully trying to sell his self-help and self-improvement technique using nine steps to reach success, but he is actually a complete loser. Her son Dwayne has taken a vow of silence as a follower of Nietzsche and aims to be a jet pilot. Dwayne's grandfather Edwin was sent away from the institution for elders (Sunset Manor) and is addicted in heroin. When her seven-year-old daughter Olive has a chance to dispute the Little Miss Sunshine pageant in Redondo Beach, California, the whole family travels together in their old Volkswagen Type 2 (Kombi) in a funny journey of hope of winning the talent contest and to make a dream come true.

Cynthia lives in London with her sullen street-sweeper daughter. Her brother has been successful with his photographer's business and now lives nearby in a more upmarket house. But Cynthia hasn't even been invited round there after a year. So, all round, she feels rather lonely and isolated. Meanwhile, in another part of town, Hortense, adopted at birth but now grown up, starts to try and trace her mother.