Rin Asogi runs a private investigation agency in Tokyo's Shinjuku district, performing odd jobs ranging from finding lost pets to hunting rare stamps in order to get by. Yet despite attempts at a normal life, she finds herself constantly hindered by the strange cases that come her way, figures from her dark past, and her inability to die.

In a post-apocalyptic future humans live in peace with androids in a domed city. However, a strange series of murders has intruded into bored inspector Re-l Mayer's life.

In the year 2046, a cop and his female android partner called Armitage, part of the latest android line known as "class III" models that look, act and feel human, investigate illegal manufacture of class III androids on colonized Mars.

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