While stuck at a wedding in Palm Springs, Nyles (Andy Samberg) meets Sarah (Cristin Milioti), the maid of honor and family black sheep. After he rescues her from a disastrous toast, Sarah becomes drawn to Nyles and his offbeat nihilism. But when their impromptu tryst is thwarted by a surreal interruption, Sarah must join Nyles in embracing the idea that nothing really matters, and they begin wreaking spirited havoc on the wedding celebration.

When renowned crime novelist Harlan Thrombey (Christopher Plummer) is found dead at his estate just after his 85th birthday, the inquisitive and debonair Detective Benoit Blanc (Daniel Craig) is mysteriously enlisted to investigate. From Harlan's disfunctional family to his devoted staff, Blanc sifts through a web of red herrings and self-serving lies to uncover the truth behind Harlan's untimely death.

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