Mysteries at the Museum is an hour-long television program on the Travel Channel which features museum artifacts of unusual or mysterious origins.

Each episode is focused on interesting and unusual artifacts held in museums. The show is hosted by Don Wildman, the executive producer is David Gerber, and the show is produced by Optomen Productions under the executive producers Nicola Moody and Dominic Stobart.

Season 10 debuted a new opening and graphics.

In the specials, Don Wildman personally visits sites and views artifacts related to a single subject.

Mysteries at the Museum is a successful series, and spawned a spin-off from its Monumental Mysteries: A Mysteries at the Museum Special called Monumental Mysteries. Monumental Mysteries and two other Travel Channel series called Hotel Secrets & Legends and Castle Secrets & Legends have been renamed Mysteries at the Monument, Mysteries at the Hotel, and Mysteries at the Castle, respectively, to capitalize on the Mysteries at the Museum name. A conspiracy show called Mysteries at the National Parks has also been developed and broadcast. The show also spawned a series of specials such as the Greatest Mysteries specials.

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