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Much to his surprise, timid Joel Barish is shocked to discover that the love of his life, sparky Clementine, has had him erased from her memory. To pay her back in the same coin, poor Joel summons up the courage to undergo a painless but intricate medical procedure to do the same, utterly unaware that darkness is an essential part of the light. Now, as hurt and angry Joel's ugly recollections of Clementine gradually fade away, giving way to a soulless black void, suddenly, he begins having second thoughts, toying with the idea of stopping the irreversible process. In the end, is ignorance really bliss?

As the light fades and the city goes to sleep, two forces emerge. They are invisible except for the power they exert over us in our sleep, battling for our souls through dreams. One force delivers hope and strength through good dreams; the other infuses the subconscious with desperation through nightmares. John and Emma, Father and Daughter are wrenched into this fantastical dream world battle, forced to fight for John's soul and to save Emma from an eternal nightmare. Separate in their journey, they encounter unusual characters that exist only in their subconscious. Or do they?

In a totalitarian society in a near future, the undercover detective Bob Arctor is working with a small time group of drug users trying to reach the big distributors of a brain-damaging drug called Substance D. His assignment is promoted by the recovery center New Path Corporation, and when Bob begins to lose his own identity and have schizophrenic behavior, he is submitted to tests to check his mental conditions.

Incarcerated and charged with murder, David Aames Jr. is telling the story of how he got to where he is to McCabe, the police psychologist. That story includes: being the 51% shareholder of a major publishing firm, which he inherited from his long deceased parents; the firm's board, appointed by David Aames Sr., being the 49% shareholders who would probably like to see him gone as they see him as being too irresponsible and immature to run the company; his best bro friendship with author, Brian Shelby; his "friends with benefits" relationship with Julie Gianni, who saw their relationship in a slightly different light; his budding romance with Sofia Serrano, who Brian brought to David's party as his own date and who Brian saw as his own possible life mate; and being in an accident which disfigured his face and killed the person who caused the accident. But as the story proceeds, David isn't sure what is real and what is a dream/nightmare as many facets of the story are incompatible to be all real. The mysterious man in the restaurant may be able to shed some light on David's confusion.

Computer scientist Hannon Fuller has discovered something extremely important. He's about to tell the discovery to his colleague, Douglas Hall, but knowing someone is after him, the old man leaves a letter in the computer generated parallel world his company has created (which looks like the 30's with seemingly real people with real emotions). Fuller is murdered in our real world the same night, and his colleague is suspected. Douglas discovers a bloody shirt in his bathroom and he cannot recall what he was doing the night Fuller was murdered. He logs into the system in order to find the letter, but has to confront the unexpected. The truth is harsher than he could ever imagine...

Astronomer Dr. Ellie Arroway has long been interested in contact to faraway lands, a love fostered in her childhood by her father, Ted Arroway (David Morse), who died when she was nine-years-old, leaving her orphaned. Her current work in monitoring for extraterrestrial life is based on that love and is in part an homage to her father. Ever since funding from the National Science Foundation (N.S.F.) was pulled on her work, which is referred to some, including her N.S.F. superior David Drumlin (Tom Skerritt), as more science fiction than science, Ellie, with a few of her rogue scientist colleagues, have looked for funding from where ever they could get it to continue their work. When Ellie and her colleagues hear chatter originating from the vicinity of the star Vega, Ellie feels vindicated. But that vindication is short lived when others, including politicians, the military, religious leaders, and other scientists, such as Drumlin, try to take over her work. When the messages received from space are decoded, the project takes on a whole new dimension, which strengthens for Ellie the quest for the truth. Thrown into the mix are the unknown person who has up until now funded most of Ellie's work and what his motivations are, and Palmer Joss (Matthew McConaughey), a renowned author and theologian, who despite their fundamental differences in outlook, is mutually attracted to Ellie, that attraction based in part on intellect and their common goal of wanting to know the truth.

Donnie Darko doesn't get along too well with his family, his teachers, and his classmates; but he does manage to find a sympathetic friend in Gretchen, who agrees to date him. He has a compassionate psychiatrist, who discovers hypnosis is the means to unlock hidden secrets. His other companion may not be a true ally. Donnie has a friend named Frank, a large bunny which only Donnie can see. When an engine falls off a plane and destroys his bedroom, Donnie is not there. Both the event, and Donnie's escape, seem to have been caused by supernatural events.

In NYC's Chinatown, recluse math genius Max (Sean Gullette) believes "everything can be understood in terms of numbers," and he looks for a pattern in the system as he suffers headaches, plays Go with former teacher Sol Robeson (Mark Margolis), and fools around with an advanced computer system he's built in his apartment. Both a Wall Street company and a Hasidic sect take an interest in his work, but he's distracted by blackout attacks, hallucinations, and paranoid delusions..

Hoping for a more exciting life than the suburban drawl he currently inhabits, nerdy salary man Morgan Sullivan takes a job as an industrial spy at Digicorp, a global computer corporation. Digicorp assigns him the duty of flying to various conventions around America, recording the speeches that are made. But when Sullivan meets a mysterious woman he begins to realize that his job may not be what it seems, as he descends into a dark underworld of brainwashing and struggles to maintain his own identity.

'Nemo Nobody' is recounting his life story to a reporter. He's less than clear, often times thinking that he is 34 years of age, others, well over 100. But his story becomes more confusing after he does focus on the fact of his current real age.

In the dystopian world of 2027 London, humans have been incapable of reproducing for 18 year for an unknown reason, meaning the imminent extinction of the species. Britain is the one remaining civilized society on the planet, which has resulted in people wanting to migrate there, so it has become a police state to handle the immigrants, who are placed into refugee camps. Lowly government bureaucrat Theo Faron, once an activist, is approached by the Fishes, deemed a terrorist group, led by his ex-wife Julian Taylor, whom he hasn't seen in almost 20 years, since their marriage disintegrated after their infant son Dylan's death during the 2008 flu pandemic. Although the Fishes did use terrorist means in their on-going revolution against the state in the fight for immigrant rights, Julian vows that they now garner support solely by speaking to the people, and she wants Theo to use his connections to get transit papers for a young immigrant woman named Kee who needs to get to the coast. Although initially reluctant to do it because of the difficulty, Theo is able to grant Julian this favor, however with the change that he now needs to accompany Kee on her journey. As Theo and Kee progress on that journey, Theo learns more and more about what's going on, including the reason that Kee needs to get to the coast, the fact that no one in the group knows if their end destination even exists, and that his and Kee's lives are in greater danger than he believed when they started the journey. But Theo's sole mission becomes to help Kee at any cost for the survival of the species.

In the not-too-distant future, a less-than-perfect man wants to travel to the stars. Society has categorized Vincent Freeman as less than suitable given his genetic make-up and he has become one of the underclass of humans that are only useful for menial jobs. To move ahead, he assumes the identity of Jerome Morrow, a perfect genetic specimen who is a paraplegic as a result of a car accident. With professional advice, Vincent learns to deceive DNA and urine sample testing. Just when he is finally scheduled for a space mission, his program director is killed and the police begin an investigation, jeopardizing his secret.

A once handsome playboy, César finds himself in a mental facility and he can't remember why. All he can remember is meeting the love of his life for one day, and then getting into a car accident which left his face horribly disfigured. But the pain of becoming physically undesirable may help him to find the truth.

PROT is a patient at a mental hospital who claims to be from a faraway planet named K-PAX. His psychiatrist tries to help him, only to begin to doubt his own explanations.

James Cole, a prisoner of the state in the year 2035, can earn parole if he agrees to travel back in time and thwart a devastating plague. The virus has wiped out most of the Earth's population and the remainder live underground because the air is poisonous. Returning to the year 1990, six years before the start of the plague, Cole is soon imprisoned in a psychiatric facility because his warnings sound like mad ravings. There he meets a scientist named Dr. Kathryn Railly and Jeffrey Goines, the mad son of an eminent virologist. Cole is returned by the authorities to the year 2035, and finally ends up at his intended destination in 1996. He kidnaps Dr. Railly in order to enlist her help in his quest. Cole discovers graffiti by an apparent animal rights group called the Army of the Twelve Monkeys, but as he delves into the mystery, he hears voices, loses his bearings, and doubts his own sanity. He must figure out if Goines, who seems to be a raving lunatic, holds the key to the puzzle.

John Murdoch awakens alone in a strange hotel to find that he has lost his memory and is wanted for a series of brutal and bizarre murders. While trying to piece together his past, he stumbles upon a fiendish underworld controlled by a group of beings known as The Strangers who possess the ability to put people to sleep and alter the city and its inhabitants. Now Murdoch must find a way to stop them before they take control of his mind and destroy him.

An impromptu goodbye party for Professor John Oldman becomes a mysterious interrogation after the retiring scholar reveals to his colleagues he has a longer and stranger past than they can imagine.

Sam Lowry (Jonathan Pryce) is a harried technocrat in a futuristic society that is needlessly convoluted and inefficient. He dreams of a life where he can fly away from technology and overpowering bureaucracy, and spend eternity with the woman of his dreams. While trying to rectify the wrongful arrest of one Harry Buttle (Brian Miller), Lowry meets the woman he is always chasing in his dreams, Jill Layton (Kim Greist). Meanwhile, the bureaucracy has fingered him responsible for a rash of terrorist bombings, and Sam and Jill's lives are put in danger.