Nothing can prepare a man for the horrors of war--and as Joey Smith, a damaged Special Forces deserter and now a homeless drug addict, wanders London's bustling streets in complete anonymity--an unexpected discovery will soon help him get back on his feet. Little by little, as Smith struggles to rebuild his shattered life in a stolen identity as an unstoppable Chinese Mafia enforcer, the brutal death of a dear friend will, inevitably, force him to avenge her murder, dragging him deeper and deeper into a dark world of pain, guilt, and suffering. In the end, do God's plans for redemption include "Crazy" Joey, too?

Sarah Ashburn, an FBI agent, is extremely ambitious and has her eye on a promotion, but she doesn't get along with her co-workers. She is sent to Boston to uncover the identity of an elusive drug lord, Mr. Larkin, by tracking down his proxy, Rojas, and is told that she'll have a good shot at the promotion if she finds Larkin. When she arrives in Boston, she learns that Larkin has been eliminating his competition and taking over their operations. She learns that Rojas is in Boston PD custody and goes to see him to ask him what he knows about Larkin, but is warned that the cop who arrested Rojas, Shannon Mullins, is very territorial, and she is not exactly sociable. When the two meet they don't get along. When Mullins learns why Ashburn is in Boston, she decides to find Larkin herself. Ashburn is told by her boss to work with Mullins, but it won't be easy because Ashburn does things by the book while Mullins does things her way.

Retired C.I.A. Agent Frank Moses (Bruce Willis) is in love with Sarah Ross (Mary-Louise Parker) and enjoying their normal life. Out of the blue, Marvin Boggs (John Malkovich) meets Frank in the supermarket and tells that Wikileaks has released the information that they had participated and know the whereabouts of the Nightshade, a portable nuclear weapon that was smuggled in pieces and hidden in Russia. Now the top agents in the world are under contract to seek them out to discover where Nightshade is. The trio travels to Paris and teams-up with the Russian Katja (Catherine Zeta-Jones) to track down the former Russian Agent "The Frog" (David Thewlis) to get more information about the operation. They learn that the brilliant inventor Dr. Edward Bailey (Sir Anthony Hopkins) might know where the weapon is. They discover that Bailey has been interned in an asylum in London by the MI6 for thirty-two years and the British Victoria (Dame Helen Mirren) joins the team. They rescue Bailey and find that the nuclear device is hidden in the Kremlin. Soon, the dangerous South Korean Han Cho Bai (Lee Byung-hun) joins the group expecting to retrieve the weapon. But dangerous killer Jack Horton (Neal McDonough) is hunting Frank down and will not stop until he recovers the nuclear bomb.

Frank (Bruce Willis) is retired, bored, and lonely living off of his government pension in a nondescript suburb in an equally nondescript house. The only joy in Frank's life is his calls to the government pension processing center when he gets to talk to his case worker, Sarah (Mary-Louis Parker). Sarah is as bored and lonely as Frank and marks her conversations with the unknown Frank and her spy novels as the only things fun in her life. When something in Frank's past forces him back into his old line of work and puts an unwitting Sarah in the middle of the intrigue, Frank and Sarah begin a journey into his past and the people with whom he used to work. Like Frank they are all "R.E.D." - Retired Extremely Dangerous.

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