In the year 199X, human civilization has been all but destroyed by a nuclear holocaust. In an age where the strong rule over the weak, the survivors of the fallout struggle over the remaining supply food and water left. Kenshiro, successor to an ancient, deadly martial art known as Hokuto Shinken (Fist of the North Star), wanders the wasteland with seven scars in the shape of the Big Dipper on his chest. This infamous style uses the body's hidden 708 pressure points to destroy opponents from within and allows practitioners to unleash 100% of their humanly strength. Accompanied by a young thief and an orphan girl, this messiah brings justice to this lawless world with the strongest fist in the world.

With demons reawakened and humanity in turmoil, a sensitive demon-boy is led into a brutal, degenerate war against evil by his mysterious friend, Ryo.

The story starts off with showing what players are and showing how Kouga and Jin were friends when they were young than the story makes a leap forward in time and follows the 2 main characters - Jin Kanzaki, a young man with the ability to transform into a superhuman being known as ZET, and Kouga Amagi, a young man with a strong sense of justice who uses technology to fight as ALPHAS. The fates of these two men and those around them intertwine as they fight to protect mankind and destroy monstrous abominations known as Players, who ironically are the creations of the Amagi Corporation, the company founded by Kouga's grandfather, Mitsugai Amagi.

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