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As any detective can tell you, investigating missing property or deaths is comparatively easy compared to elusive missing people. However in New York City, there is a special unit of the FBI that is designed to find them. Using the vast resources of their bureau, the team, lead by Agent Jack Malone, race against time in the tight 72 hour window after a disappearance while hope for a recovery is still typically possible.

Former CIA operative is lured back to his old life when the NYPD needs his help to stop a serial killer. Dr. Dylan Reinhart (Alan Cumming) is a gifted author and university professor living a quiet life teaching psychopathic behavior to packed classes of adoring students. But when top NYPD detective Lizzie Needham (Bojana Novakovic) appeals to him to help her catch a serial murderer who is using Dylan's first book as a tutorial, Dylan is compelled by the case, comes out of retirement and taps into his old skill set. Though Dylan and Lizzie initially clash, when it comes to catching killers, they realize they will make an ideal team if they both trust their instincts. Based on the James Patterson book.

She disappeared. No one heard from her for six years. No one knows what happened to her, not even her. An FBI Agent tracking a Boston serial killer vanishes, and is declared dead. Six years later, she is found in a cabin in the woods, with no memory of what happened during the time she went missing. She comes back to a husband who has remarried, and whose wife is raising her son. She will have to navigate in her new reality, and she will soon find herself implicated in a new series of murders.

In the Los Angeles office of the Federal Bureau of Investigation, Special Agent Don Eppes and his team investigate critical and baffling crimes with a special edge. That advantage is Don's brother, Charles Eppes, a brilliant universalist mathematician who uses the science of mathematics with its complex equations to ferret out the most tricky criminals. With this team, the forces of evil learn their number is up.

Lilly Rush is a Philadelphia police detective working for the department's homicide squad and being assigned "cold cases": crimes that were committed many years before and have not been solved. Lilly must try to re-think the crime scenes and interview other people involved with the victims to find a link to solving the cases.

Malcolm Bright, one of the best criminal psychologists around, uses his twisted genius to help the NYPD solve crimes.

On the streets of San Francisco a team of the Federal Bureau of Investigation's Behavioral Analysis Unit use profiling to catch some of the most horrific serial killers and unidentifiable subjects.

Carrie Wells, a former police detective, has a rare ability to remember virtually everything she experiences including detailed visual recall. She returns to police work and uses her ability to solve crimes.

Brilliant, but socially inept, forensic anthropologist Dr. Temperence Brennan works at the Jeffersonian Institute in Washington DC. After consulting for him on a FBI case, she is approached by cocky yet charming Former Army Ranger turned Special Agent, Seeley Booth to help the Bureau solve crimes by identifying human remains that are too far gone for standard FBI forensic investigations. Brennan's empirical, literal view of the world causes friction with Booths emotive, instinctive attitude creating a volatile relationship. However as their case load increases the symbiotic partnership produces results and with the support of Brennan's Squint Squad, murderers, past and present should be on the look out.

The best private pathologist in Miami, Dr. Beaumont Rosewood, Jr., whose rare heart condition that could kill him at any moment fuels his lust for life, gives a second opinion when friends or family of the deceased are not satisfied with official police findings. His state-of-the-art laboratory equipment, Sherlock Holmes-like powers of deduction and quick wit are his main tools. He also relies and depends on his trusty assistants and cute couple, Pippy and TMI, and works with no-nonsense detective Annalise Villa, who doesn't always go strictly by the book, to see the case to its conclusion.

Deputy Police Chief Brenda Leigh Johnson, formerly Atlanta police officer and CIA-trained interrogator, is given the opportunity to run her own division of elite officers of the Los Angeles Police Department. Her unusual procedure for obtaining confessions, blatant disregard for politics, and southern accent make her a marked woman. However, with all the bluster and bravado, she still maintains her title, The Closer.

A private investigator in Los Angeles reluctantly teams up with a former star of a hit cop show.

A look at the professional and personal lives of people working at a family-run hotel in Miami Beach.

CBS's successful CSI franchise gets transplanted to the Big Apple. Cases involving sewer rats as witnesses, a victim whose head was slammed in a pizzeria oven, and murders of commodities traders, and--of course--a Red Sox fan. CSI: NY is a bleaker, grimmer version of its Las Vegas and Miami cousins. The team is made up of a pleasantly New Yawk but indistinct cast of characters. The teams leader Detective Mac Taylor (Gary Sinise), is a former Marine from Chicago. Mac is a veteran of the NYPD who lost his wife on 9/11, and as such must work to rebuild his personal life while supervising his team. He is organized, efficient, dedicated, and very proper in his management style. His second in command for the first 6 seasons is Detective Stella Bonasera (Melina Kanakaredes), Stella is half-Greek, half-Italian, and entirely New York City. She helped Mac through the impact of his wife's death and has been by his side ever since. She is a savvy investigator, yet she often speaks before she thinks. Stella leaves New York to head a crime lab in New Orleans and is replaced by Detective Jo Danville (Sela Ward). Jo is a former FBI criminalist and an experienced psychological profiler. She and Mac quickly form a strong friendship and an even stronger working rapport. Jo is still haunted by her ousting from the FBI after blowing the whistle on improper lab procedure, so she works to regain her professional reputation. Joining them is younger CSIs Danny Messer (Carmine Giovinazzo), Aiden Burn (Vanessa Ferlito, who has since left the show), Aiden's replacement Lindsay Monroe (Anna Belknap) and medical examiner turned CSI Sheldon Hawkes (Hill Harper). Rounding out the cast is the teams legal muscle Homicide Detective Don Flack (Eddie Cahill), Medical Examiner Sid Hammerback, M.D. (Robert Joy) and lab tech Adam Ross (A. J. Buckley).

Detective Jane Rizzoli and Chief Medical Examiner Dr. Maura Isles team up to solve crimes in Boston.

Having lost her medical license in the aftermath of a family tragedy, Megan Hunt M.D. joined the medical examiners and proved herself a forensic genius. Yet even diplomatic Medico-legal Investigator Pete Dunlop can't prevent her arrogant attitude and total disregard for any authority or social norm to cause grave aggravation all around. Still, as long as the perpetrators suffer most, the bulldozer approach pays off on the balance.

Dr. Cal Lightman teaches a course in body language and makes an honest fortune exploiting it. He's employed by various public authorities in various investigations, doing more when the police etc. fail to go the extra mile. So he can afford to constitute a team of his own, which like clients and others has to put up with his mind-games.

After the unsolved murder of his wife, Trudy, Adrian Monk develops obsessive-compulsive disorder, which includes his terror of germs and contamination. His condition costs him his job as a prominent homicide detective in the San Francisco Police Department, but he continues to solve crimes with the help of his assistant and his former boss.