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ROYAL PAINS centers on a young E.R. doctor who, after being wrongly blamed for a patient's death, moves to the Hamptons and becomes the reluctant "doctor for hire" to the rich and famous. When the attractive administrator of the local hospital asks him to treat the town's less fortunate, he finds himself walking the line between doing well for himself and doing good for others.

A highly articulate, erudite and intelligent businessman and mastermind, "Red" Reddington, has allegedly been on the "10 Most Wanted List" of various U.S. law enforcement agencies for over 20 years. The legend is that Red is as elusive as he is clever, controlling a labyrinth of creative enterprises, coupled with uncanny ability to gather and finesse information at the drop of a hat. On the first day at FBI for a new female profiler fresh out of Quantico, Red offers to bandy wits with the FBI. Red promises to deliver various criminals and plots previously unknown to any branch of law enforcement... and all Red requests in return is to choose his muse.

A superstar magician Cameron Black whose career is ruined by scandal has only one place to turn to practice his art of deception, illusion, and influence, the FBI where he'll become the world's first consulting illusionist, helping the government solve crimes that defy explanation, and trap criminals and spies by using deception.

Lawyers and lifelong friends Jared Franklin and Peter Bash are recruited by a large firm's major partner after winning a high-profile case.

In the Los Angeles office of the Federal Bureau of Investigation, Special Agent Don Eppes and his team investigate critical and baffling crimes with a special edge. That advantage is Don's brother, Charles Eppes, a brilliant universalist mathematician who uses the science of mathematics with its complex equations to ferret out the most tricky criminals. With this team, the forces of evil learn their number is up.

A former Chicago cop moves to a small Florida town and joins the state police.

Carrie Wells, a former police detective, has a rare ability to remember virtually everything she experiences including detailed visual recall. She returns to police work and uses her ability to solve crimes.

Brilliant, but socially inept, forensic anthropologist Dr. Temperence Brennan works at the Jeffersonian Institute in Washington DC. After consulting for him on a FBI case, she is approached by cocky yet charming Former Army Ranger turned Special Agent, Seeley Booth to help the Bureau solve crimes by identifying human remains that are too far gone for standard FBI forensic investigations. Brennan's empirical, literal view of the world causes friction with Booths emotive, instinctive attitude creating a volatile relationship. However as their case load increases the symbiotic partnership produces results and with the support of Brennan's Squint Squad, murderers, past and present should be on the look out.

A woman, who quit being an attorney at her father's law firm to become a mediator, copes after her father's death.

Richard "Rick" Castle is a millionaire playboy who recently killed off his main character when a serial killer starts killing people like he does in his books. He teams up with New York police detective Kate Beckett to solve the case. He finds inspiration in Detective Beckett and starts shadowing her for his next book.

Travis Marks and Wes Mitchell are police detective partners with wildly differing personalities. Marks is a charmer with the ladies and Mitchell is a methodical former lawyer. They can't stand one another. Their boss, fed up with conflict, sends them off to have couples therapy.

Detective Jane Rizzoli and Chief Medical Examiner Dr. Maura Isles team up to solve crimes in Boston.

Think you are psychic? Shawn Spencer (James Roday) makes his living pretending to be. Shawn and his best friend Burton "Gus" Gu ster (Dulé Hill) own a business called "Psych". They are able to stay in business only because of the cases they work with the Santa Barbara Police Department as psychics. Shawn and Gus go through many ups and downs trying to keep the ruse up. Can they pretend forever? Or is the world they built going to come crumbling down?

Dr. Cal Lightman teaches a course in body language and makes an honest fortune exploiting it. He's employed by various public authorities in various investigations, doing more when the police etc. fail to go the extra mile. So he can afford to constitute a team of his own, which like clients and others has to put up with his mind-games.

After the unsolved murder of his wife, Trudy, Adrian Monk develops obsessive-compulsive disorder, which includes his terror of germs and contamination. His condition costs him his job as a prominent homicide detective in the San Francisco Police Department, but he continues to solve crimes with the help of his assistant and his former boss.

A New York City homicide Detective cracks case after case while raising wild twin boys and locking horns with her less than helpful Police Detective ex-husband.

Patrick Jane is a crime consultant with the California Bureau of Investigation. He has a particular gift for astute observation and reading people, honed through years of being a faux psychic. His gift makes him brilliant at solving murders, which is why the CBI have him around. However, his motive for taking on the role is purely one of revenge: find and kill the man who killed his wife and daughter - Red John.

A disgraced former NYPD officer lives with his son, an earnest, obsessively honest NYPD detective.