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Based in Quantico, Virginia, the Behavioral Analysis Unit (B.A.U.) is a subsection of the F.B.I. Called in by local Police departments to assist in solving crimes of a serial and/or extremely violent nature where the perpetrator is unknown (referred to by the Unit as the unknown subject or "unsub" for short), the B.A.U. uses the controversial scientific art of profiling to track and apprehend the unsub. Profiling entails coming up with basic characteristics of the unsub and the victims (referred to as the victimology), using evidence from the case and matching that information to historic precedents and psychological analyses as a means to solve the case. Because of the nature of the work conducted by the B.A.U. - the work being time consuming and psychologically demanding - its members are fiercely loyal to the Unit and to its other members. Also because of the work's overall demanding nature, not many members of the B.A.U. have been able to maintain a happy or stable family life.

ROYAL PAINS centers on a young E.R. doctor who, after being wrongly blamed for a patient's death, moves to the Hamptons and becomes the reluctant "doctor for hire" to the rich and famous. When the attractive administrator of the local hospital asks him to treat the town's less fortunate, he finds himself walking the line between doing well for himself and doing good for others.

A highly articulate, erudite and intelligent businessman and mastermind, "Red" Reddington, has allegedly been on the "10 Most Wanted List" of various U.S. law enforcement agencies for over 20 years. The legend is that Red is as elusive as he is clever, controlling a labyrinth of creative enterprises, coupled with uncanny ability to gather and finesse information at the drop of a hat. On the first day at FBI for a new female profiler fresh out of Quantico, Red offers to bandy wits with the FBI. Red promises to deliver various criminals and plots previously unknown to any branch of law enforcement... and all Red requests in return is to choose his muse.

A superstar magician Cameron Black whose career is ruined by scandal has only one place to turn to practice his art of deception, illusion, and influence, the FBI where he'll become the world's first consulting illusionist, helping the government solve crimes that defy explanation, and trap criminals and spies by using deception.

Ethically-challenged attorney Alan Shore, formerly of Young, Frutt & Berluti, settles in at a wealthy and powerful firm focusing on civil cases. With some help from his friend and mentor, veteran attorney Denny Crane, Shore quickly makes his mark winning cases no one would take, often using less than honest methods. In doing so, he develops a rival in his colleague Brad Chase, who has been assigned to the office partly to keep an eye on the increasingly eccentric (and possibly senile) Denny Crane. Though his questionable conduct might make him a few enemies along the way, Alan's not one to be underestimated, nor will he let trivial things like honesty or integrity get in the way of winning a case.

Carrie Wells, a former police detective, has a rare ability to remember virtually everything she experiences including detailed visual recall. She returns to police work and uses her ability to solve crimes.

Brilliant, but socially inept, forensic anthropologist Dr. Temperence Brennan works at the Jeffersonian Institute in Washington DC. After consulting for him on a FBI case, she is approached by cocky yet charming Former Army Ranger turned Special Agent, Seeley Booth to help the Bureau solve crimes by identifying human remains that are too far gone for standard FBI forensic investigations. Brennan's empirical, literal view of the world causes friction with Booths emotive, instinctive attitude creating a volatile relationship. However as their case load increases the symbiotic partnership produces results and with the support of Brennan's Squint Squad, murderers, past and present should be on the look out.

Richard "Rick" Castle is a millionaire playboy who recently killed off his main character when a serial killer starts killing people like he does in his books. He teams up with New York police detective Kate Beckett to solve the case. He finds inspiration in Detective Beckett and starts shadowing her for his next book.

Travis Marks and Wes Mitchell are police detective partners with wildly differing personalities. Marks is a charmer with the ladies and Mitchell is a methodical former lawyer. They can't stand one another. Their boss, fed up with conflict, sends them off to have couples therapy.

Deputy Police Chief Brenda Leigh Johnson, formerly Atlanta police officer and CIA-trained interrogator, is given the opportunity to run her own division of elite officers of the Los Angeles Police Department. Her unusual procedure for obtaining confessions, blatant disregard for politics, and southern accent make her a marked woman. However, with all the bluster and bravado, she still maintains her title, The Closer.

Detective Jane Rizzoli and Chief Medical Examiner Dr. Maura Isles team up to solve crimes in Boston.

Think you are psychic? Shawn Spencer (James Roday) makes his living pretending to be. Shawn and his best friend Burton "Gus" Gu ster (Dulé Hill) own a business called "Psych". They are able to stay in business only because of the cases they work with the Santa Barbara Police Department as psychics. Shawn and Gus go through many ups and downs trying to keep the ruse up. Can they pretend forever? Or is the world they built going to come crumbling down?

Brilliant LAPD detective Charlie Crews has survived the extreme abuse befalling an innocent cop in prison, and was exonerated for the murders and released after 12 years of hell in jail. He could retire on his settlement, but chooses to resume police work. Nevertheless, the grim experience has made him more philosophical and tempted to put justice - especially for the innocent - above chasing the presumably guilty and legally by-the-book, as his new partner Dani Reese must experience and learn to cope with.

Walter Clark is destined to be the youngest police commissioner in the history of the NYPD. This is the story of how it came to be. It begins 7 years before he became commissioner, when he was a rookie cop who saved the life of his partner who was shot and a hostage. This was witnessed by several people, and he would get promoted to detective and offered the position of his choice. Clark asks to be assigned to a homicide task force. When he arrives, one of the detectives who was the star of the unit until Clark arrived resents his presence. And the detective assigned to him feels as if he's babysitting him. But Clark sets out to do the best job he can.

Dr. Cal Lightman teaches a course in body language and makes an honest fortune exploiting it. He's employed by various public authorities in various investigations, doing more when the police etc. fail to go the extra mile. So he can afford to constitute a team of his own, which like clients and others has to put up with his mind-games.

After the unsolved murder of his wife, Trudy, Adrian Monk develops obsessive-compulsive disorder, which includes his terror of germs and contamination. His condition costs him his job as a prominent homicide detective in the San Francisco Police Department, but he continues to solve crimes with the help of his assistant and his former boss.

A New York City homicide Detective cracks case after case while raising wild twin boys and locking horns with her less than helpful Police Detective ex-husband.

Patrick Jane is a crime consultant with the California Bureau of Investigation. He has a particular gift for astute observation and reading people, honed through years of being a faux psychic. His gift makes him brilliant at solving murders, which is why the CBI have him around. However, his motive for taking on the role is purely one of revenge: find and kill the man who killed his wife and daughter - Red John.