The final chapter of the Dr. Hannibal Lecter quadrilogy, the murdering cannibal. He is presently in Italy, and works as a curator at a museum. Clarice Starling (Julianne Moore), the F.B.I. Agent who he aided to apprehend a serial killer, was placed in charge of an operation, but when one of her men botches it, she's called to the mat by the Bureau. One high ranking official, Paul Krendler (Ray Liotta) has it in for her. But she gets a reprieve because Mason Verger (Gary Oldman), one of Lecter's victims who is looking to get back at Lecter for what Lecter did to him, wants to use Starling to lure him out. When Lecter sends her a note, she learns that he's in Italy, so she asks the Police to keep an eye out for him. But a corrupt Policeman, who wants to get the reward that Verger placed on him, tells Verger where he is, but they fail to get him. Later, Verger decides to frame Starling, which makes Lecter return to the U.S., and the race to get Lecter begins.

Mort Rainey is a successful writer going through a rather unfriendly divorce from his wife of ten years, Amy. Alone and bitter in his cabin, he continues to work on his writing when a stranger named John Shooter shows up on his doorstep, claiming Rainey stole his story. Mort says he can prove the story belongs to him and not Shooter, but while Mort digs around for the magazine which published the story in question years ago, things begin to happen around Shooter. Mort's dog dies, people begin to die, and his divorce proceedings with Amy continue to get uglier. It seems that Shooter has Mort over a barrel, but perhaps Mort has his own ideas on how to resolve all the problems that plague him lately.

After his wife, Alice, tells him about her sexual fantasies, William Harford sets out for a night of sexual adventure. After several less than successful encounters, he meets an old friend, Nick Nightingale--now a musician--who tells him of strange sex parties where he is required to play the piano blindfolded. All the men at the party are costumed and wear masks while the women are all young and beautiful. Harford manages to find an appropriate costume and heads out to the party. Once there, however, he is warned by someone who recognizes him, despite the mask, that he is in great danger. He manages to extricate himself, but the threats prove to be quite real and sinister.

Chicago advertising executive Charles 'Chaz' Schine is mentally worn down by his useless teacher wife Deanna and their equally ingrate daughter Amy, whose bad diabetes requires experimental, uncovered treatment that would exhaust their life savings. When foxy investment adviser Lucinda Harris volunteers to pay his ticket when he arrive son the commuter train without cash, they soon start an affair. Taking her to a tacky hotel, they are held at gunpoint by thug 'Frenchie' LaRoche, who rapes her having knocked Chaz down, robs their wallets and calls him afterward, blackmailing a small fortune not to tell his wife. Paying through equally abusive Dexter only incurs more demands and abuse, until Chaz brings along ex con office mail boy Winston Boyko, who promises to scare away, but is shot by LaRoche, leaving Chaz to deal with the corpse, police detective Church being a friend of Winston's. Only when bled dry, Chaz finds out Lucinda is a stolen identity, part of an elaborate setup. His ill-planned vengeance, as lawyer friend Jerry sees no legal way without timely complaints from him and Lucinda, starts a cycle of bloodshed and other unpleasant surprises for most involved.

Four tales of crime adapted from Frank Miller's popular comics, focusing around a muscular brute who's looking for the person responsible for the death of his beloved Goldie (Jaime King), a man fed up with Sin City's corrupt law enforcement who takes the law into his own hands after a horrible mistake, a cop who risks his life to protect a girl from a deformed pedophile and a hitman looking to make a little cash.

2005 film directed by Frank Miller and Robert Rodriguez

After her mother commits suicide in the bathtub, Emily Callaway is taken to live upstate in new surroundings to forget her traumatic past. Psychologist David, her father, learns that his daughter has a new friend, the enigmatic, never to be seen, imaginary (or not?) Charlie. A deadly game of hide-and-seek ensues. Who is Charlie? And what is troubling David in his dreams?

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