On the night of an astronomical anomaly, eight friends at a dinner party experience a troubling chain of reality bending events.

Dr. Edward Pretorius and his assistant, the physician Crawford Tillinghast, have developed the Resonator, a machine to stimulate the sixth sense through the pineal gland. When Crawford activates the apparatus, he sees creatures flying in the air and he summons Dr. Pretorius. The experiment goes out of control and Dr. Pretorius refuses to turn off the Resonator. Meanwhile their neighbor calls the police, and when the police officers arrive, they see Crawford trying to escape from his house and Dr. Pretorius beheaded. Crawford is sent to a mental institution under the supervision of the sadistic Dr. Bloch. However, the prominent psychiatrist Dr. Katherine McMichaels requests the custody of Crawford and Detective Bubba Brownlee that is investigating the case stays with them. Katherine goes with Crawford and Bubba to see the Resonator and turns the machine on. Dr. Pretorius returns in a mutant shape and attacks them, in the beginning of a gore night with weird life forms.

Marshal O'Niel's assigned to a mining colony on Io, one of Jupiter's moons. He soon encounters miners who are dying, due to use of an illegal amphetamine. O'Niel follows the trail, and now O'Niel must watch his back, as he's now their target.

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