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Based in Quantico, Virginia, the Behavioral Analysis Unit (B.A.U.) is a subsection of the F.B.I. Called in by local Police departments to assist in solving crimes of a serial and/or extremely violent nature where the perpetrator is unknown (referred to by the Unit as the unknown subject or "unsub" for short), the B.A.U. uses the controversial scientific art of profiling to track and apprehend the unsub. Profiling entails coming up with basic characteristics of the unsub and the victims (referred to as the victimology), using evidence from the case and matching that information to historic precedents and psychological analyses as a means to solve the case. Because of the nature of the work conducted by the B.A.U. - the work being time consuming and psychologically demanding - its members are fiercely loyal to the Unit and to its other members. Also because of the work's overall demanding nature, not many members of the B.A.U. have been able to maintain a happy or stable family life.

Leonard Hofstadter and Sheldon Cooper are both brilliant physicists working at Cal Tech in Pasadena, California. They are colleagues, best friends, and roommates, although in all capacities their relationship is always tested primarily by Sheldon's regimented, deeply eccentric, and non-conventional ways. They are also friends with their Cal Tech colleagues mechanical engineer Howard Wolowitz and astrophysicist Rajesh Koothrappali. The foursome spend their time working on their individual work projects, playing video games, watching science-fiction movies, or reading comic books. As they are self-professed nerds, all have little or no luck with women. When Penny, a pretty woman and an aspiring actress from Omaha, moves into the apartment across the hall from Leonard and Sheldon's, Leonard has another aspiration in life, namely to get Penny to be his girlfriend.

People all over the U.S and the world start to realize they have special abilities, like telekinesis, healing abilities, flying powers, time travel, invisibility, and the ability to absorb other's abilities. One man, known as Sylar, wants to gain all the power of these "heroes" so he can be the most powerful and evolved human of all, and stops at nothing to gruesomely kill these people. In order to protect themselves from him, these people must help one another before Sylar can destroy them all, while they each deal with problems of their own.

John Winchester raised his two sons Sam and Dean to hunt and kill all things that go "bump in the night" after his wife Mary was murdered by an evil supernatural being when the boys were little. 22 years later the brothers set out on a journey, fighting evil along the way, to find their recently-missing father; when they finally do he reveals he knows what demon killed their mother and has found a way to track and kill it. Meanwhile, Sam develops frightening abilities such as seeing visions of people dying before it actually happens. These visions are somehow connected to the demon that murdered his mother and its mysterious plans that seem to be all about Sam. When their father dies striking a deal with that very same demon, the brothers determine to finish his crusade. But disturbing revelations about Sam's part in the demon's apocalyptic plan are presented when John's dying last words to Dean are revealed.

Michael Westen, a seasoned U.S. spy, is suddenly "burned", i.e. discredited, without any form of procedure. He survives by doing impossible jobs for desperate people in Miami, where his mother lives. Michael is usually aided by his ex-girlfriend Fiona and trusted former FBI informer Sam.

Portland detective, Nick Burkhardt, has seen some gruesome crime scenes, but nothing prepares him for the strange visions he begins seeing: seemingly regular people momentarily transforming into hideous monsters. A visit from his only living relative reveals the truth. Nick has inherited the ability to see supernatural creatures, and as a "Grimm," he is tasked with keeping the balance between mankind and the mythological. A reformed "Big Bad Wolf" becomes his greatest (and also reluctant) ally and confidant. It's not long before his work as a policeman leads Nick to the criminals he once thought were only found in fairy tales.

In the Los Angeles office of the Federal Bureau of Investigation, Special Agent Don Eppes and his team investigate critical and baffling crimes with a special edge. That advantage is Don's brother, Charles Eppes, a brilliant universalist mathematician who uses the science of mathematics with its complex equations to ferret out the most tricky criminals. With this team, the forces of evil learn their number is up.

Brilliant, but socially inept, forensic anthropologist Dr. Temperence Brennan works at the Jeffersonian Institute in Washington DC. After consulting for him on a FBI case, she is approached by cocky yet charming Former Army Ranger turned Special Agent, Seeley Booth to help the Bureau solve crimes by identifying human remains that are too far gone for standard FBI forensic investigations. Brennan's empirical, literal view of the world causes friction with Booths emotive, instinctive attitude creating a volatile relationship. However as their case load increases the symbiotic partnership produces results and with the support of Brennan's Squint Squad, murderers, past and present should be on the look out.

Ted Mosby sits down with his kids, to tell them the story of how he met their mother. The story is told through memories of his friends Marshall, Lily, Robin, and Barney Stinson. All legendary 9 seasons lead up to the moment of Ted's final encounter with "the one."

He's smart, he's good looking, and he's got a great sense of humor. He's Dexter Morgan, everyone's favorite serial killer. As a Miami forensics expert, he spends his days solving crimes, and nights committing them. But Dexter lives by a strict code of honor that is both his saving grace and lifelong burden. Torn between his deadly compulsion and his desire for true happiness, Dexter is a man in profound conflict with the world and himself. Golden Globe winner Michael C. Hall stars in the hit SHOWTIME Original Series.

Think you are psychic? Shawn Spencer (James Roday) makes his living pretending to be. Shawn and his best friend Burton "Gus" Gu ster (Dulé Hill) own a business called "Psych". They are able to stay in business only because of the cases they work with the Santa Barbara Police Department as psychics. Shawn and Gus go through many ups and downs trying to keep the ruse up. Can they pretend forever? Or is the world they built going to come crumbling down?

The past, present, and future lives of surviving Oceanic Flight 815 passengers are dramatically intertwined as a fight for survival ensues in a quest for answers after crashlanding on a mysterious island. Each discovery prompts yet more secrets, as the hastily-formed colony search for a way off the island, or is this their home?

A billionaire software-genius named Harold Finch creates a Machine for the government that is designed to detect acts of terror before they can happen, by monitoring the entire world through every cell-phone, email and surveillance camera. Finch discovered that the machine sees everything, potential terrorist acts and violent crimes that involve ordinary people. When the government considered violent crimes between normal people "irrelevant", Finch built a back door into the system that gives him the social security number of a person involved in a future violent crime so he could act. Partnered with John Reese, an ex-CIA agent, the two work in secret to prevent violent crimes before they can happen. Eventually their activities lead to being hunted by the New York Police Department, CIA Agents in pursuit of Reese who was listed as dead, a computer hacker named Root who wants access to the Machine, and government officials who want to keep all knowledge of the Machine a complete secret.

In this modernized version of the Conan Doyle characters, using his detective plots, Sherlock Holmes lives in early 21st century London and acts more cocky towards Scotland Yard's detective inspector Lestrade because he's actually less confident. Doctor Watson is now a fairly young veteran of the Afghan war, less adoring and more active.

Set in the fictional Sacred Heart hospital in California, John "J.D" Dorian makes his way through the overwhelming world of medicine, with the help of his best friend, his fellow rookie doctors, and the arrogant, but brilliant attending physician he views as his mentor.

Dr. Cal Lightman teaches a course in body language and makes an honest fortune exploiting it. He's employed by various public authorities in various investigations, doing more when the police etc. fail to go the extra mile. So he can afford to constitute a team of his own, which like clients and others has to put up with his mind-games.

After the unsolved murder of his wife, Trudy, Adrian Monk develops obsessive-compulsive disorder, which includes his terror of germs and contamination. His condition costs him his job as a prominent homicide detective in the San Francisco Police Department, but he continues to solve crimes with the help of his assistant and his former boss.

Since geeky Chuck accidentally became the mental host of the Intersect, an unprecedentedly powerful computer mind containing all information available to the US government, he's a primordial national security asset and risk. So CIA and NSA each appoint a top agent to guard Chuck, and often get involved with him in spy adventures. Meanwhile his identity must be kept secret from Chuck's sister, her perfect partner Devon, both surgeons, and Chuck's goofy colleagues in Buy More, the Burbank electronics store where he works as a cover.