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Dr. Horrible, an aspiring supervillain with his own video blog, is attempting to join the prestigious Evil League of Evil (led by the legendary "thoroughbred of sin", Bad Horse), but his plans are usually foiled by the egotistical superhero Captain Hammer. Horrible's life is thrown for a loop when he falls in love with Penny, a beautiful and optimistic advocate for the homeless he meets at the laundromat, a situation which complicates itself even further when Penny begins dating the boorish, oafish Hammer after he apparently saves her life. Faced with the task of impressing the League, can Horrible overcome his own incompetence to ruin the day, kill the hero, and still get the girl?

Dethklok is the biggest, baddest, and most famous heavy metal band in the world. The quintet, consisting of Americans Nathan Explosion (vocals), William Murderface (bass), and Pickles the Drummer, along with Scandinavian guitarists Toki Wartooth and Skwisgaar Skwigelf, have to deal with their fame and other situations in their lives, all the while being monitored by a government organization out to destroy them.

Stand back, ignorant Earth filth. Invader Zim has been sent from the planet IRK on a mission of doom. Disguised as a child and accompanied by GIR, his robot, Zim has come to assume control of Earth. But, a wrench named Dib interferes with his plan.

On his 21st birthday, Sam discovers his parents sold his soul to the devil before birth and he must now be a bounty hunter for the devil until he dies.

In the distant past, a Japanese samurai (Phil LaMarr) embarks on a mission to defeat the evil shape-shifting wizard Aku (Mako and Greg Baldwin). Before he can complete his task, though, he is catapulted thousands of years into the future. He finds himself in a world where Aku now enjoys complete power over every living thing. Dubbing himself "Jack", he sets out on a new quest - to right the wrongs that have been done by his enemy, and to find a way back to his own time so he can destroy the evil for good.

The year is 2040; Bruce Wayne has retired as Batman and Gotham City is without a symbol of hope. However, like the Phoenix rising from the ashes, a new Batman will take Bruce's place: in the form of his newfound errand-boy, Terry McGinnis. The legend lives on. Batman goes beyond the Wayne legacy and into uncharted territory, making new enemies, friends, and reasons for why the world still needs Batman in it.

The warped misadventures of a former boy adventurer turned washed-up, middle-aged mad scientist Dr. Rusty Venture; his moronic teenage sons; their maniac bodyguard; and the Doctor's arch-nemeses, incompetent super villain The Monarch and his masculine sounding paramour, Dr. Girlfriend.

Philip J. Fry is a twenty-five-year-old pizza delivery boy whose life is going nowhere. When he accidentally freezes himself on December 31, 1999, he wakes up one thousand years in the future, and has a chance to make a fresh start. He goes to work for the Planet Express Corporation, a futuristic delivery service that transports packages to all five quadrants of the universe. His companions include the delivery ship's Captain, Leela, a beautiful one-eyed female alien who kicks some serious butt, and Bender, a robot with very human flaws.

In the Dark Ages, there was a race of heroic warrior monsters known as Gargoyles. These creatures existed as stone during the day, but become flesh and blood at night. One Scottish clan made an alliance with humans to help protect a castle by night if the humans would protect their stone forms by day. The uneasy alliance was shattered when human prejudice provoked a betrayal that allowed the castle to be sacked and most of the resident clan destroyed, leaving only six adult survivors and a rookery of unhatched eggs. A further misunderstanding during the clan's retaliation on the invaders and rescue of their hostages left the clan frozen in stone by a magic spell that would only be broken when the "castle rises above the clouds." For a thousand years, the castle laid abandoned and the clan condemned by this curse. In 1994, a wealthy multibillionare named David Xanatos (Jonathan Frakes) bought the castle and transported the whole structure to Manhattan, where he placed it on top of the Eyrie building which he owned. It is high enough to be above the clouds, thus the conditions of the spell were met and the Gargoyles were revived. Now, this clan must adjust to this new age and gain friends, like Detective Elisa Maza (Salli Richardson-Whitfield), who reveals that Xanatos revived them to exploit them for his unscrupulous ends. This is coupled by the fact that another Gargoyle comrade, Demona (Marina Sirtis), is alive from their age, and is now an insane renegade bent on the extermination of humanity. Rebelling against them, the clan abandon the castle and pledge to protect New York City like they protected the castle in the past.

Meet Georgia Lass (who prefers to be called George). She is a young Seattle college dropout who is unhappy with life. She is always at odds with her mom, Joy. One day coming back from her temp job as a filing clerk, she is hit by the toilet seat of the re-entering Space Station Mir. Finding out she is now dead, she is recruited to become a grim reaper. As in life, she is a pain in the butt in death. She does not like the details of her job, and is always at loggerheads with her boss Rube. Her fellow grim reapers don't really take much of a liking to her either. She also learns grim reapers don't even get a free ride in death, as they must hold down regular jobs along with their death duties.

In a major city, Robin the Boy Wonder leads his own team of superheroes, The Teen Titans. With his teammates, the dark Raven, the powerful Cyborg, the flighty alien princess Starfire and the flippant Beast Boy; the team battles the forces of evil where ever they appear like the enigmatic Slade, the diabolical Brother Blood or the malevolently cosmic Trigon.

Harvey Birdman, the superhero formerly known as Birdman, is now a practicing (and dimwitted) lawyer. His cases always involve legal disputes between cartoon characters. Past cases involve custody of Jonny Quest, a copyright infringement case between the Chan Clan and Jabberjaw, and Fred Flintstone's possible mob connections.

Neil accidentally ends up in the Legend of Zelda.

Computer geek Dexter Douglas (David Haufman) turns into uncontrollable, unpredictable superhero Freakazoid (Paul Rugg), who dons red long underwear, blue skin, and weird hair. The transformation occurs while Dexter surfs on the internet. As a superhero, he fights crime whenever he sees it perpetrated by goofy villains, with his friends Steff (Tracy Rowe) and Sergeant Mike Cosgrove (Edward Asner).

The extraordinary adventures of life within a computer, as depicted in one of the world's first totally-computer-generated series. The riotous humour, infinitely-variable action and scenery, and intelligent use of every computer reference known, combine to produce a stunning universe where good constantly fights the forces of evil. Dot Matrix and her brother Enzo, plus thousands of friendly binomes, live in Mainframe, which is plagued by viruses Megabyte and sister strain Hexadecimal. Guardian Bob is sent from the Net to protect them, and soon makes it his home. Together, they must prevent Megabyte from taking control of all the systems. As an added complication, games being played by the mystical User invade the system regularly, and must be defeated, or else portions of the city are laid waste... This gives us a chance to see every genre of video-game ever conceived, from the point of view of the characters! When Megabyte finally manages to banish Bob, Enzo takes over as the city's Guardian, but things will never be quite the same...

The show revolves around the lives of online guild, The Knights of Good, who play countless hours of an unnamed MMORPG video game. The story focuses on Codex, the guild's Priestess, who attempts to lead a normal life after one of her guild-mates, Warlock Zaboo, shows up on her doorstep.

Take New York City, add every horrifying beast, science-fiction freak, and fantasy faerie, shake thoroughly, and you've got Ugly Americans.

The vampire Angelus, now known as Angel, has a human soul, but committed terrible crimes in the past. Seeking forgiveness and trying to redeem himself, he moves from Sunnydale (and a relationship with Buffy Summers, of "Buffy the Vampire Slayer") to Los Angeles, where he helps the downtrodden by thwarting the supernatural creatures that prey on them.