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Ryan Bingham is a corporate downsizing expert whose cherished life on the road is threatened just as he is on the cusp of reaching ten million frequent flyer miles, and just after he's met the frequent-traveller woman of his dreams.

Melanie Parker, an architect and mother of Sammy, and Jack Taylor, a newspaper columnist and father of Maggie, are both divorced. They meet one morning when overwhelmed Jack is left unexpectedly with Maggie and forgets that Melanie was to take her to school. As a result, both children miss their school field trip and are stuck with the parents. The two adults project their negative stereotypes of ex-spouses on each other, but end up needing to rely on each other to watch the children as each must save his job. Humor is added by Sammy's propensity for lodging objects in his nose and Maggie's tendency to wander.

Soon after moving in, Beth, a brainy, beautiful writer damaged from a past relationship encounters Adam, the handsome, but odd, fellow in the downstairs apartment whose awkwardness is perplexing. Beth and Adam's ultimate connection leads to a tricky relationship that exemplifies something universal: truly reaching another person means bravely stretching into uncomfortable territory and the resulting shake-up can be liberating.

Homer is an orphan in remote St. Cloud, Maine. Never adopted, he becomes the favorite of orphanage Director Dr. Larch, who imparts his full medical knowledge on Homer, who becomes a skilled, albeit unlicensed, physician. But Homer yearns for a self-chosen life outside the orphanage. When Wally and pregnant Candy visit the orphanage, Dr. Larch provides a medically safe, albeit illegal, abortion, Homer leaves with them to work on Wally's family apple farm. Wally goes off to war, leaving Homer and Candy alone together. What will Homer learn about life and love in the cider house? What of the destiny that Dr. Larch has planned for him?

Finding it hard to settle down and commit himself to only one woman, the unrepentant philanderer and undeniable ladies' man, Alfie, is a charming British bachelor who cruises the streets of New York as a limousine chauffeur. In his impeccable suits, the silver-tongued Casanova is simply irresistible; however, things will take a turn for the unexpected, when a night of unrestrained passion seriously tests Alfie's frivolous approach to life. In the end, is Alfie happy, and, above all, what's it all about, then?

Smart-but-ineffectual journalist Dan "We use euphemisms!" cannot decide between his girlfriend, loving-but-clingy waitress Alice, or his lover cold-but-intellectual photographer Anna; herself indecisive between Dan and honest-but-thuggish "You're bloody gorgeous!" doctor Larry. The film puts the four leading characters in a box and strips them apart.

Dean Pereira and Cindy Heller Pereira are a young, working class married couple - Dean currently working as a painter, and Cindy working as a nurse in a medical clinic - with a young daughter named Frankie. Despite their relatively tender ages, they are both ravaged by the life they've eked out together and by the experiences they've had leading into their marriage. Dean, a high school drop out, comes from a broken home, where he never really had a mother figure. He never saw himself getting married or having a family despite falling in love at first sight with Cindy. He doesn't have any professional ambition beyond his current work - which he enjoys since he feels he can knock off a beer at 8 o'clock in the morning without it affecting his work - although Cindy believes he has so much more potential in life. Cindy also comes from a dysfunctional family, with her own mother and father not setting an example of a harmonious married or family life. One of her previous serious relationships was with Bobby Ontario, that relationship which has a profound affect on many aspects of her marriage to Dean. Dean and Cindy head off on an overnight getaway together without Frankie, the getaway which may provide a clearer picture if their marriage can survive its many issues.

Adrienne Willis, a woman with her life in chaos, retreats to the tiny coastal town of Rodanthe, in the Outer Banks of North Carolina, to tend to a friend's inn for the weekend. Here she hopes to find the tranquility she so desperately needs to rethink the conflicts surrounding her -- a wayward husband who has asked to come home, and a teen-aged daughter who resents her every decision. Almost as soon as Adrienne gets to Rodanthe, a major storm is forecast and a guest named Dr. Paul Flanner arrive. The only guest at the inn, Flanner is not on a weekend escape but rather is there to face his own crisis of conscience. Now, with the storm closing in, the two turn to each other for comfort and, in one magical weekend, set in motion a life-changing romance that will resonate throughout the rest of their lives...

A woman finds a romantic letter in a bottle washed ashore and tracks down the author, a widowed shipbuilder whose wife died tragically early. As a deep and mutual attraction blossoms, the man struggles to make peace with his past so that he can move on and find happiness.

Two sisters, plus a dead mother, a remarried father, and a hostile step-mother. The sisters, each in her way, have perfected the art of losing. The elder, Rose, is an attorney, responsible, lonely, with a closet full of shoes. The younger is Maggie, beautiful, selfish, and irresponsible. Her drunken behavior gets her tossed by her step-mother from her dad's house; worse behavior gets her tossed from Rose's apartment. Then, while searching in her father's desk for money to filch, Maggie finds an address; the past and the future open up to her and, with any luck, may open to her sister as well.

Almost forty years ago, a young girl of fourteen has sex, gets pregnant, and gives her baby up for adoption. Fast-forwarding to the present day, we meet three very different women, each of whom struggles to maintain control of their lives. There's Elizabeth, a smart and successful lawyer who uses her body to her advantage. Any time she feels that she doesn't have the upper hand, and cannot control the situation, she uses her sex appeal - whether that be starting a romance with her boss when she suspects he is trying to start one himself, or finding some way to control her overly friendly neighbor and husband. Karen, meanwhile, is a bitter health care professional who obviously has a lot of heart but never shows it. She gave up a daughter at the age of fourteen (wonderfully shown rather than told, she is the young girl and mother of Elizabeth), and has never gotten over it - her bitterness inspiring her to lash out at everyone around her - even the gentle man at work who is undeniably drawn to her. Finally, Lucy is a woman who has failed to conceive with her husband, so she turns to adoption to make the family she desires.

This love story has Kitty (Naomi Watts) meeting young, intelligent, shy and somewhat dull Dr. Walter Fane (Edward Norton), whose forte is the study of infectious diseases, and the convenient marriage to which she finds herself committed. It is in this web of intrigue that they head for China, only after Walter discovers Kitty's infidelity with the dashing and witty diplomat Charlie Townsend (Liev Schreiber). So much as to hide her from herself and to help thwart a cholera outbreak, this is a marriage more than on the rocks. This is a cold, indifferent, and loveless partnership in a vast unknown and deadly environment that will test both of these flightless lovebirds and with the hardships and tolerances more than any had ever anticipated. A visual delight amidst the pain and suffering of dying people and failing marriage. Will a cure be found for both, before it's too late?

Maggie (Hathaway) is an alluring free spirit who won't let anyone - or anything - tie her down. But she meets her match in Jamie (Gyllenhaal), whose relentless and nearly infallible charm serve him well with the ladies and in the cutthroat world of pharmaceutical sales. Maggie and Jamie's evolving relationship takes them both by surprise, as they find themselves under the influence of the ultimate drug: love.

Holly Kennedy is beautiful, smart and married to the love of her life - a passionate, funny, and impetuous Irishman named Gerry. So when Gerry's life is taken by an illness, it takes the life out of Holly. The only one who can help her is the person who is no longer there. Nobody knows Holly better than Gerry. So it's a good thing he planned ahead. Before he died, Gerry wrote Holly a series of letters that will guide her, not only through her grief, but in rediscovering herself. The first message arrives on Holly's 30th birthday in the form of a cake, and to her utter shock, a tape recording from Gerry, who proceeds to tell her to get out and "celebrate herself". In the weeks and months that follow, more letters from Gerry are delivered in surprising ways, each sending her on a new adventure and each signing off in the same way; P.S. I Love You. Holly's mother and best friends begin to worry that Gerry's letters are keeping Holly tied to the past, but in fact, each letter is pushing her further into a new future. With Gerry's words as her guide, Holly embarks on a journey of rediscovery in a story about marriage, friendship and how a love so strong can turn the finality of death into a new beginning for life.

In a nursing home, resident Duke reads a romance story to an old woman who has senile dementia with memory loss. In the late 1930s, wealthy seventeen year-old Allie Hamilton is spending summer vacation in Seabrook. Local worker Noah Calhoun meets Allie at a carnival and they soon fall in love with each other. One day, Noah brings Allie to an ancient house that he dreams of buying and restoring and they attempt to make love but get interrupted by their friend. Allie's parents do not approve of their romance since Noah belongs to another social class, and they move to New York with her. Noah writes 365 letters (A Year) to Allie, but her mother Anne Hamilton does not deliver them to her daughter. Three years later, the United States joins the World War II and Noah and his best friend Fin enlist in the army, and Allie works as an army nurse. She meets injured soldier Lon Hammond in the hospital. After the war, they meet each other again going on dates and then, Lon, who is wealthy and handsome, proposes. Meanwhile Noah buys and restores the old house and many people want to buy it. When Allie accidentally sees the photo of Noah and his house in a newspaper, she feels divided between her first love and her commitment with Lon. Meanwhile Duke stops reading to the old lady since his children are visiting him in the nursing home.

The love which binds mother and daughter - seen through the prism of one mother's life as it crests with optimism, navigates a turning point, and ebbs to its close. Overcome by the power of memory, Ann Lord (Vanessa Redgrave) reveals a long-held secret to her concerned daughters; Constance Haverford (Natasha Richardson), a content wife and mother, and Nina Mars (Toni Collette), a restless single woman. Both are bedside when Ann calls out for the man she loved more than any other. But who is this "Harris", wonder her daughters, and what is he to our mother? While Constance and Nina try to take stock of Ann's life and their own lives, their mother is tended to by a night nurse (Dame Eileen Atkins) as she journeys in her mind back to a summer weekend around fifty years before, when she was Ann Grant (Claire Danes), a young woman who has come from New York City to be maid of honor at the high-society Newport wedding of her dearest friend from college, Lila Wittenborn (Mamie Gummer). The bride-to-be is jittery, and turns to her maid of honor rather than her own mother for support. Ann stays close to her friend, yet is even closer to Lila's irrepressible brother Buddy Wittenborn (Hugh Dancy). Unexpected feelings surge forth once Ann meets wedding guest Harris Arden (Patrick Wilson), a life-long friend and intimate of the Wittenborn family. Ann's love for Harris will change her life, and those of her daughters, forever.

Griffin is divorced, living in a flat in Manhattan while his sons and ex live in the family home in Westchester. He gets bad news from his oncologist: cancerous lesions have spread through his chest, and he has only a year or so to live. He audits a psychology class on death and dying at a nearby college where he chats up a woman who turns out to be an assistant dean. She's Phoenix; she smiles but keeps her distance, warming to him slowly. He tells her nothing of his situation. At his apartment a few days later, she finds a stash of books on death, dying, and terminal illness: will she put two and two together, and what will she do about it?

Twelve year old Marcus Brewer lives with his chronically depressed single mother, Fiona Brewer. Both Fiona and Marcus beat to their own respective drummers. Marcus will do whatever he can to make his depressed mother happy, even if it causes himself grief. As such, he realizes that he is perceived as different than most kids, as even the self-professed weird kids don't want to hang out with him as he is the target of bullying. Part of the taunts against him are the fact that he sings and speaks to himself without even realizing that he is doing it. Meanwhile, thirty-eight year old Will Freeman is a slacker who has lived comfortably off the royalties of a song written by his deceased father, and as such has never had to work a day in his life. He is a solitary man who places himself as the first and only priority in life. He comes across the idea that dating single moms meets his selfish carnal needs. It is in this capacity that Will meets Marcus, as one of Will's single mother conquests, Suzie, is friends with the Brewers. Trying to escape his life but wanting Will to date Fiona, Marcus infiltrates Will's life, much to Will's chagrin. Will slowly begins to realize that Marcus is more than just a nuisance, but rather someone who needs some guidance navigating through the trials of adolescence and the trials of dealing with a suicidal mother, and perhaps he can be a small part of providing that direction. Conversely, Marcus may be able to show Will the path to becoming a real adult.