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Detective Catherine Chandler (Kristin Kreuk), shaken to the core over the fact that everything she thought she knew about her life has been a lie, is determined to get answers to the secrets that have been revealed about her family. Cat must also try to navigate her evolving relationship with handsome doctor Vincent Keller (Jay Ryan), who struggles with becoming a terrifying beast when he is enraged, unable to control his super-strength and heightened senses. Cat and Vincent continue to grapple with the desire to be a normal couple while trying to keep a low profile in order to stay one step ahead of the mysterious organization known as Muirfield, now on the hunt for both of them.

Chloe King should be dead. Any normal human being would be under the circumstances, but Chloe has just turned sixteen and has found out she isn't as normal as she once thought she was. Chloe is Mai - a race of beings with cat-like powers: speed, agility, and claws. Being a high school student was complicated enough, but being Mai has added a new set of problems. Chloe is given the responsibility of protecting both the Mai and Human races. A secret organization wants to have her assassinated - nine times if necessary. And a simple kiss has deadly consequences; so much for falling in love.

"Therapist" Dr. Tom - who is constantly spouting famous and not so famous historical quotes - is Erica Strange's savior and worst enemy. Erica, a young adult woman, is having a bad life because of the bad decisions she's made. Erica provides Dr. Tom with a long list of those pivotal moments in her life that she feels have led to the bad state she is in today. Erica is initially unaware of what Dr. Tom is intending on doing with this list. What he does do is transport her back in time to each of those moments so that she, with all the knowledge of her present day life, can make better decisions to fix her life. Regardless of these new decisions, Dr. Tom hopes that Erica will come to the realization that although the opinions of others about her life do matter, it's what she thinks of her decisions and her life that are more important.

Henry Morgan is a man who's been alive for 200 years and he doesn't know why and has spent the past 200 years trying to find out. Presently he works as a medical examiner in New York. Detective Jo Martinez works with him and is intrigued with him. Abe is the only one who knows Henry's secret.

For Emma Swan, life has been anything but a happy ending. But when she's reunited with Henry - the son she gave up for adoption ten years ago - on the night of her 28th birthday, everything changes. The now 10-year-old Henry is in desperate need of Emma's help because he believes from reading a book of fairy-tales that she's the daughter of Snow White and Prince Charming - who sent her away from the Enchanted Forest to be protected from a curse that was enacted by the Evil Queen. Emma initially refuses to believe a word of Henry's story but soon finds that his hometown of Storybrooke, Maine is more than it seems. Because it's in Storybrooke that all of the classic characters we know are frozen in time with no memories of their former selves - except for the Evil Queen, who is Storybrooke's mayor and Henry's adoptive mother Regina Mills. Now, as the epic "Final Battle" for the future of both worlds approaches, Emma will have to accept her destiny and uncover the mystery behind a place where fairy-tales are to be believed.

A relationship forms between a gifted young girl and a man sprung from prison who has been tasked with protecting her from the evil elements that hunt her power.

A Seattle family takes in an amnesiac teen (Dallas), whom they eventually learn has mysterious powers and psychic abilities, the result of a secret human cloning experiment conducted years earlier. The family helps teach Kyle human behaviors such as anger, joy and love, and guards him against forces who seek to use Kyle for their own nefarious purposes.

As a summer to remember begins in the Hamptons, new arrival Emily Thorne dazzles the members of high society by making herself known in the exclusive social circle of Grayson Global CEO Conrad Grayson and his socialite wife Victoria. But it soon becomes clear that the beguiling young philanthropist has a dark past. Emily was once known as Amanda Clarke, a young eight-year-old (in the summer of 1993) whose life was torn apart when her father - Grayson Global hedge fund manager David Clarke - was falsely accused of channeling money to a terrorist organization responsible for the downing of a commercial airliner. Now living under an assumed identity, she is determined to seek vengeance on the people who destroyed her father's life - the two main conspirators being Conrad and Victoria Grayson - by making their lives come crashing down around them. Because when everything you love has been stolen from you, someone has to pay.

The Powells are a typical American family living in Pacific Bay, California, whose members gain special powers after their plane crashes in the Amazon.

Michael Holt is a successful doctor who has a thriving practice. One day he runs into his ex-wife Anna, also a doctor. They spend some time together. He later learns that she died before he met her. He goes to her memorial and learns she was working in an inner-city clinic, and when he goes there, he can't help but assist. Before long, people from the clinic come to see him. He continues to see Anna, who tries to get him to do good. He decides to work at the clinic as well as at his practice.

Widower Martin Bohm's wife, Sarah Bohm, died in the twin towers on September 11, 2001. Previously a newspaper journalist, Martin since has worked a series of odd jobs in trying to make sense of his life, which includes caring for his son Jake, who was born on October 26, 2000. Jake was diagnosed as autistic, primarily because he has never uttered a word, and has an aversion to being touched. But Martin begins to believe that there is more to Jake's life than meets the eye. Jake, using a series of numbers, leads Martin to discoveries about a certain equilibrium to the world. Martin may ultimately find out what Jake's grand purpose is, and why Jake was placed on the face of the Earth.

15-year-old foster-care vet Lux has finally decided to become an emancipated minor. During her journey through the legal maze, she finds her biological father, 32-year-old Nate "Baze" Bazile, who lives above a bar and is astonished to learn that he has a daughter, and finally her biological mother, Cate Cassidy, a local-radio star with a fiancé, Ryan Thomas. A judge decides to grant temporary custody of Lux to Baze and Cate instead of emancipating her.

16-year-old Cassie moves from California to live with her grandmother in Chance Harbor, Washington, and falls in love with a mysterious boy named Adam. But, when she enrolls in high school there, she realizes that he, she and all the other elite students at the school are witches. She befriends their leader, Diana, but soon discovers that Adam and Diana are dating, which leads to drama.

The psychiatrist seeking to save his sister as well his patients while using any means necessary.

A young paramedic discovers he has telepathic powers.

Fast-talking New Yorker and brand-new doctor Zoe Hart has it all figured out: after graduating top of her class from medical school, she'll follow in her father's footsteps and become a cardio-thoracic surgeon. But when her dream falls apart, Zoe decides to accept an offer from a stranger, Dr. Harley Wilkes, to work with him at his small practice in Bluebell, Alabama. Zoe arrives in this small Gulf Coast town only to find that Harley has passed away and left his half of the medical practice to her in his will.

Melinda Gordon inherited her "gift" - the ability to see and talk with the spirits of dead people - from, and was coached in its use by her grandmother. Running an antique store in a small town, newly married to a paramedic, Melinda helps the ghosts wandering around who are trapped between worlds by helping them to resolve unfulfilled aspects of their former life.

A mysterious man bestows unique powers to three women.