Maggie (Hathaway) is an alluring free spirit who won't let anyone - or anything - tie her down. But she meets her match in Jamie (Gyllenhaal), whose relentless and nearly infallible charm serve him well with the ladies and in the cutthroat world of pharmaceutical sales. Maggie and Jamie's evolving relationship takes them both by surprise, as they find themselves under the influence of the ultimate drug: love.

In North Carolina especially in Beaufort a prank on a guy goes wrong and puts the student in the clinic. Carter, a famous student with no plans for the future, is held responsible and forced to join in after-school community service activities as consequence, which include starring as the lead in the play. And participating in these activities is Jamie Sullivan, the reverend's daughter who has great ambitions and nothing in common with Landon. When Landon decides he wants to take his activities seriously, he asks Jamie for help and begins to spend most of his time with her. But he starts to like her, that he did not expect to do. They relationship, much to the chagrin of Landon's old popular friends and Jamie's strict reverend father. But when a heart-breaking secret becomes known that puts their relationship to the test, it is then that Landon and Jamie realize the true meaning of love and fate.

18-year-old Matthew Kidman is a straight 'A' over-achiever who feels that he has never really lived life to the full. That is, until he meets 'the girl next door'. Danielle moves in next door, and Matthew thinks he's found the girl of his dreams. All is going well, until Matthew's sex-mad friend Eli reveals that Danielle is actually a ex-porn star. Matthew doesn't know how to take the news or how to treat Danielle, and things go from bad to worse when Danielle's former producer Kelly appears to take her back.