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Six New Yorkers juggle love, friendship, and the keenly challenging specter of adulthood. Sam Wexler is a struggling writer who's having a particularly bad day. When a young boy gets separated from his family on the subway, Sam makes the questionable decision to bring the child back to his apartment and thus begins a rewarding, yet complicated, friendship. Sam's life revolves around his friends-Annie, whose self-image keeps her from commitment; Charlie and Mary Catherine, a couple whose possible move to Los Angeles tests their relationship; and Mississippi, a cabaret singer who catches Sam's eye.

Ryan Bingham is a corporate downsizing expert whose cherished life on the road is threatened just as he is on the cusp of reaching ten million frequent flyer miles, and just after he's met the frequent-traveller woman of his dreams.

Meet the Borgens. William Borgens is an acclaimed author who hasn't written a word since his ex-wife Erica left him 3 years ago for another man. In between spying on Erica and casual romps with his married neighbour Tricia, Bill is dealing with the complexities of raising his teenage children Samantha and Rusty. Samantha is publishing her first novel and is determined to avoid love at all costs - after all she's seen what it has done to her parents. In between hook ups, she meets "nice guy" Lou who will stop at nothing to win her over. Rusty, is an aspiring fantasy writer and Stephen King aficionado, who is on a quest to gain 'life experiences'. He falls for the beautiful, but troubled Kate and gets his first taste of love and a broken heart. A tale of family, love (lost and found), and how endings can make new beginnings. There are no rewrites in life, only second chances.

Soon after moving in, Beth, a brainy, beautiful writer damaged from a past relationship encounters Adam, the handsome, but odd, fellow in the downstairs apartment whose awkwardness is perplexing. Beth and Adam's ultimate connection leads to a tricky relationship that exemplifies something universal: truly reaching another person means bravely stretching into uncomfortable territory and the resulting shake-up can be liberating.

L.A. soft-porn writer Carter Webb is frustrated enough, after his actress girlfriend dumps him, to need a serious break. He decides to spend it with his grandmother, who can't really take care of herself and her Detroit suburb house anyway. Helpful Carter soon overcomes mishaps to bond with the foxy neighbor across the street and her daughters. Helping them actually helps him regain perspective and self-confidence.

After it looks as if she's left his life for good this time, Tom Hansen reflects back on the just over one year that he knew Summer Finn. For Tom, it was love at first sight when she walked into the greeting card company where he worked, she the new administrative assistant. Soon, Tom knew that Summer was the woman with whom he wanted to spend the rest of his life. Although Summer did not believe in relationships or boyfriends - in her assertion, real life will always ultimately get in the way - Tom and Summer became more than just friends. Through the trials and tribulations of Tom and Summer's so-called relationship, Tom could always count on the advice of his two best friends, McKenzie and Paul. However, it is Tom's adolescent sister, Rachel, who is his voice of reason. After all is said and done, Tom is the one who ultimately has to make the choice to listen or not.

Cal (Steve Carell) and Emily (Julianne Moore) have the perfect life together living the American dream... until Emily asks for a divorce. Now Cal, Mr Husband, has to navigate the single scene with a little help from his professional bachelor friend Jacob Palmer (Ryan Gosling). Make that a lot of help...

Thirty-five-year-old Jesse Fisher, an admissions officer at a New York City post-secondary institution he who loves English and literature, has somewhat lost his passion in life, which includes recently being unceremoniously dumped by his latest girlfriend, who could no longer be the person to prop him up emotionally. He has a chance to find that passion again when he is invited to the retirement dinner of his second-favorite Ohio University college professor, Peter Hoberg, as his time there was when his life held the most passion. Jesse's encounters with five people there may determine if he does find that passion again. They are: Hoberg, who is resisting the notion of retirement; Judith Fairfield, Jesse's favorite professor, although for a different reason than his like of Hoberg; Nat, a free spirit who navigates life at the institution on his own terms; undergraduate student Dean, who Jesse sees as a younger more destructive version of himself; and nineteen-year-old undergraduate student Zibby, who is seemingly wise beyond her years and with who Jesse embarks on a relationship despite their sixteen-year-age difference.

In North Carolina especially in Beaufort a prank on a guy goes wrong and puts the student in the clinic. Carter, a famous student with no plans for the future, is held responsible and forced to join in after-school community service activities as consequence, which include starring as the lead in the play. And participating in these activities is Jamie Sullivan, the reverend's daughter who has great ambitions and nothing in common with Landon. When Landon decides he wants to take his activities seriously, he asks Jamie for help and begins to spend most of his time with her. But he starts to like her, that he did not expect to do. They relationship, much to the chagrin of Landon's old popular friends and Jamie's strict reverend father. But when a heart-breaking secret becomes known that puts their relationship to the test, it is then that Landon and Jamie realize the true meaning of love and fate.

Against medical advice and without the knowledge of her husband Pat Solatano Sr., caring Dolores Solatano discharges her adult son, Pat Solatano Jr., from a Maryland mental health institution after his minimum eight-month court ordered stint. The condition of the release includes Pat Jr. moving back in with his parents in their Philadelphia home. Although Pat Jr.'s institutionalization was due to him beating up the lover of his wife Nikki, he was diagnosed with bipolar disorder. Nikki has since left him and has received a restraining order against him. Although he is on medication (which he doesn't take because of the way it makes him feel) and has mandatory therapy sessions, Pat Jr. feels like he can manage on the outside solely by healthy living and looking for the "silver linings" in his life. His goals are to get his old job back as a substitute teacher, but more importantly reunite with Nikki. He finds there are certain instances where he doesn't cope well; however, no less so than some others who have never been institutionalized, such as his Philadelphia Eagles obsessed father who has resorted to being a bookie to earn a living, his best friend Ronnie who quietly seethes over the control wielded by his wife Veronica, and Veronica's widowed sister, Tiffany Maxwell, a girl with problems of her own. In their fragile mental states, Pat Jr. and Tiffany embark on a love/hate friendship based primarily on what help the other can provide in achieving their individual goals. But they may reevaluate their goals as their relationship progresses.

After a little white lie about losing her virginity gets out, a clean cut high school girl sees her life paralleling Hester Prynne's in "The Scarlet Letter," which she is currently studying in school - until she decides to use the rumor mill to advance her social and financial standing.

Holly Kennedy is beautiful, smart and married to the love of her life - a passionate, funny, and impetuous Irishman named Gerry. So when Gerry's life is taken by an illness, it takes the life out of Holly. The only one who can help her is the person who is no longer there. Nobody knows Holly better than Gerry. So it's a good thing he planned ahead. Before he died, Gerry wrote Holly a series of letters that will guide her, not only through her grief, but in rediscovering herself. The first message arrives on Holly's 30th birthday in the form of a cake, and to her utter shock, a tape recording from Gerry, who proceeds to tell her to get out and "celebrate herself". In the weeks and months that follow, more letters from Gerry are delivered in surprising ways, each sending her on a new adventure and each signing off in the same way; P.S. I Love You. Holly's mother and best friends begin to worry that Gerry's letters are keeping Holly tied to the past, but in fact, each letter is pushing her further into a new future. With Gerry's words as her guide, Holly embarks on a journey of rediscovery in a story about marriage, friendship and how a love so strong can turn the finality of death into a new beginning for life.

In a nursing home, resident Duke reads a romance story to an old woman who has senile dementia with memory loss. In the late 1930s, wealthy seventeen year-old Allie Hamilton is spending summer vacation in Seabrook. Local worker Noah Calhoun meets Allie at a carnival and they soon fall in love with each other. One day, Noah brings Allie to an ancient house that he dreams of buying and restoring and they attempt to make love but get interrupted by their friend. Allie's parents do not approve of their romance since Noah belongs to another social class, and they move to New York with her. Noah writes 365 letters (A Year) to Allie, but her mother Anne Hamilton does not deliver them to her daughter. Three years later, the United States joins the World War II and Noah and his best friend Fin enlist in the army, and Allie works as an army nurse. She meets injured soldier Lon Hammond in the hospital. After the war, they meet each other again going on dates and then, Lon, who is wealthy and handsome, proposes. Meanwhile Noah buys and restores the old house and many people want to buy it. When Allie accidentally sees the photo of Noah and his house in a newspaper, she feels divided between her first love and her commitment with Lon. Meanwhile Duke stops reading to the old lady since his children are visiting him in the nursing home.

In 1957, when second-graders Bryce Loski and Julianna "Juli" Baker first meet, Juli knows it's love, but Bryce isn't so sure and tries to avoid Juli. By the sixth grade, in 1961, Bryce tries to get rid of Juli by dating Sherry Stalls, whom Juli despises. However, Bryce's best friend, Garrett, takes an interest in Sherry and eventually tells her the truth about Bryce asking her out; she doesn't take it well. From Juli's perspective, Bryce returned her feelings, but was shy. After finding out Bryce and Sherry broke up, she thought she could have Bryce back. But then they reconsider their decisions as time goes on. In 1962, Bryce's grandfather Chet Duncan moves in with the family. Chet has different views about Juli. There's a large, old sycamore tree that Juli loves which no one else understands. One day, it's cut down by a group of landscapers so a house can be built there, despite Juli's opposition. She becomes very depressed afterwards, as the tree let her see the world in a more enlightened way. Her father gives her a painting of the tree.

Craig is a high-school junior in the gifted program, infatuated with his best friend's girl. When he realizes he's suicidal, he checks himself into the psychiatric ward of a hospital, thinking they'll do an observation, help him, and send him home in time for school the next day. Once in, however, he must stay for a week; the juvenile ward is being renovated, so he's in with adults as well as a few youths. Bobby, a man with a young daughter, shows him around; Craig notices Noelle, about his age. He tries to keep his friends from finding out where he is. He draws, goes to therapy, sings, helps Bobby rehearse an interview. Is this the stuff of insight?

The needy Gigi Haim is a young woman seeking her prince charming somewhere amongst her unsuccessful dates. After dating estate agent Conor Barry, Gigi anxiously expects to receive a phone call from him. However Conor never calls her. Gigi decides to go to the bar where he frequents to see him, but she meets his friend Alex who works there. They become friends and Alex helps Gigi to interpret the subtle signs given out by her dates.

Believing the quote that you are born alone, die alone and everything else is an illusion, George doesn't see the point of life, school, or homework. Then he meets Sally and he now has a reason to go to school and make friends, even if he's not ready to admit to himself or to her that he likes her. The school's principal and art teacher introduce him to an alumni, and successful artist, Dustin, who can help guide George along life's path, but other distractions start surfacing, and George might not even be able to graduate from high school.

Leo and Paige are a couple who just got married. After an accident, Paige is left unconscious, and when she awakes she doesn't remember Leo. Her parents, whom she hasn't seen since she and Leo got together, come and visit her. She can't believe that she hasn't seen them for such a long time. Leo wants to bring her home with him but her parents want her to go with them. She goes with Leo but when she doesn't recognize anything, she goes to her parents. And she wonders why did she cut off contact with her family. She also runs into her ex and wonders why they broke up. Leo tries to win her back by courting her again.