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Citizens of the Universe, also referred to as 'COTU', is a guerrilla theatre specializing in 'found space' performances and is currently headquartered in Charlotte, North Carolina. There are branches of COTU also located in Orlando, Florida, Baltimore, Maryland, and Greenville, South Carolina.

COTU was founded in 2001 by James Cartee and Andrew Bryant in Greenville, South Carolina with core artist Dan A. R. Kelly, Jason Bryant and Traysie Amick. COTU's work ranges from original works and foreign language pieces to classics with a recent focus on films that have been adapted for stage.

In 2004, the group's production of Arthur Miller's The Creation of the World and Other Business was banned from playing at Greenville Technical College.