The Drew Barrymore Show (often shortened to Drew) is a first-run syndicated American talk show hosted by actress Drew Barrymore. The show is distributed by CBS Media Ventures and debuted on September 14, 2020. In April 2022, the show was renewed for a third season.

The program features human-interest stories, celebrity guests, lifestyle segments and field pieces.

Barrymore shot a pilot for the show in New York in August 2019, aiming for a fall 2020 launch. Barrymore had previously circled a talk show deal with Warner Bros.' Telepictures in 2016, but a pilot never came to fruition, in part because of a lukewarm response from prospective station groups at the time.

Barrymore debuted several digital series in the lead-up to her broadcast debut that included “The Making of the Drew Barrymore Show” and conversations with talk-show hosts who have inspired her in “The Art of the Interview.” This particular series included Barrymore's conversations with Gayle King, Andy Cohen, Jimmy Fallon, Whoopi Goldberg, and Sean Evans.

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