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Fatale is a supernatural noir comic book created by Ed Brubaker and Sean Phillips. It was published by Image Comics between January 2012 and July 2014. The series was initially announced as a 12-issue limited series, but was later extended to 24 issues.

The series was originally announced in the back of the final issue of Brubaker and Phillips' previous collaboration, Criminal: Last of the Innocent. Further details about the series, including its publisher, were revealed at the 2011 New York Comic Con. Brubaker also released a video teaser for the series.

The series began publishing monthly in January 2012. Although initially billed as a twelve-issue series, the length was increased in November. The series concluded after 24 issues.