Holy Ghost! is an American synthpop duo from Brooklyn, New York City. Founded in 2007, the duo consists of Nick Millhiser and Alex Frankel.

Millhiser and Frankel both grew up on the Upper West Side of New York City and attended Trevor Day School together. They were later part of a hip hop group called Automato. Automato's debut album was produced by James Murphy and Tim Goldsworthy of DFA. According to Frankel, after the release of the album, Automato "kind of fell apart". Millhiser and Frankel kept working on music, their collaboration having already begun moving towards the alternative dance genre.

The name Holy Ghost! was selected just before the pressing of their debut single "Hold On" in November 2007. The single was described by Resident Advisor as "one of the dirtiest little Italo tunes you're likely to hear this year".

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