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Protemnodon is an extinct genus of megafaunal macropodids that existed in Australia, Tasmania, and New Guinea in the Pliocene and Pleistocene. It is also called the giant kangaroo.

Recent analysis of mtDNA extracted from fossils indicates that Protemnodon was closely related to Macropus. The species formerly known as Protemnodon bandharr and Protemnodon buloloensis have been moved to a new genus, Silvaroo, while the New Guinean species P. nombe has been moved to the new genus Nombe.

Based on fossil evidence, Protemnodon is thought to have been physically similar to wallabies, but generally larger and more robust. Protemnodon nombe was the smallest in the genus, weighing about 45 kg; Protemnodon roechus was the largest in the genus, weighing around 170 kg.