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Tranquility Base Hotel & Casino Tour was the sixth headlining concert tour by English indie rock band Arctic Monkeys in support of their sixth studio album, Tranquility Base Hotel & Casino. The tour began on 2 May 2018 in San Diego, United States at The Observatory North Park and concluded on 7 April 2019 in Bogotá, Colombia at Estéreo Picnic Festival. This marks their first tour since AM Tour (2013–2014).

The group announced their first North American headlining shows since 2014 and several festival dates on 12 March 2018. On 5 April, the group announced the release of their sixth studio album, Tranquility Base Hotel & Casino, to be released on 11 May. The group announced United Kingdom and Ireland dates on 9 April. In April, they announced extra dates in United Kingdom and United States. In November, the group announced Latin America dates.