The Immortal Life of Henrietta Lacks is a drama television film directed by George C. Wolfe and starring Oprah Winfrey and Rose Byrne. It is based on the book of the same name by Rebecca Skloot and documents the story of Henrietta Lacks, who was diagnosed with cervical cancer in the 1950s, and whose cancer cells (later known as HeLa) would change the course of cancer treatment. The film premiered on HBO on April 22, 2017.

The film was announced on May 2, 2016 with Alan Ball and Oprah Winfrey as executive producers. George C. Wolfe would direct the film, with Winfrey taking the role of Lacks' daughter Deborah. In July, Rose Byrne was cast as Rebecca Skloot, the author of the book about Henrietta, who befriends Deborah while reporting on her mother's life, and Renée Elise Goldsberry was cast as the titular Henrietta Lacks. The core supporting cast was rounded out in August 2016, with Courtney B. Vance, Ruben Santiago-Hudson, Reg E. Cathey and Leslie Uggams amongst them. After several weeks of shooting in Atlanta, The Immortal Life of Henrietta Lacks began filming in Baltimore in September, 2016. Two of Henrietta Lacks's sons, Zakariyya and Sonny, were consultants on the film.

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