Wait Wait... Don't Tell Me! is an hour-long weekly news radio panel show produced by WBEZ and National Public Radio (NPR) in Chicago, Illinois. On the program, panelists and contestants are quizzed in humorous ways about that week's news. It is distributed by NPR in the United States, internationally on NPR Worldwide and on the Internet via podcast, and typically broadcast on weekends by member stations. The show averages about six million weekly listeners on air and via podcast.

Wait Wait... Don't Tell Me! was usually recorded in front of a live audience in Chicago at the Chase Auditorium beneath the Chase Tower on Thursday nights. They also do tours around the country performing in front of a live audience. Due to the COVID-19 pandemic, in the spring of 2020 they converted to recording remotely, largely from their homes, and had sound effects and a virtual audience added for broadcast. Beginning in August 2021, they have held in-person recordings, when possible, with a live audience. Starting with the June 11, 2022 episode, the show returned to having a live audience every week in the Studebaker Theater.

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