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the emperor of all maladies

The Emperor of All Maladies: A Biography of Canceris a book written by Siddhartha Mukherjee, an Indian-born American physician and oncologist. Published on 16 November 2010 by Scribner, it won the 2011 Pulitzer Prize for General Non-Fiction: the jury called it "an elegant inquiry, at once clinical and personal".

The book weaves together Mukherjee's experiences as a hematology/oncology fellow at Massachusetts General Hospital as well as the history of cancer treatment and research. Mukherjee gives the history of cancer from its first identification 4,600 years ago by the Egyptian physician Imhotep. The Greeks had no understanding of cells, but they were familiar with hydraulics. Hippocrates thus considered illness to be an imbalance of four cardinal fluids: blood, black bile, yellow bile, phlegm. Galen applied this idea to cancer, believing it to be an imbalance of black bile. In 440 BCE, the Greek historian Herodotus recorded the first breast tumor excision of Atossa, the queen of Persia and the daughter of Cyrus, by a Greek slave named Democedes. The procedure was believed to have been successful temporarily. Galen's theory was later challenged by the work of Andreas Vaselius and Matthew Baille, whose dissections of human bodies failed to reveal black bile.

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