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A.P. Bio is an American comedy television series created by Mike O'Brien for NBC. After a pilot order in late January 2017, the project was ordered to series on May 8, 2017. The series premiered on February 1, 2018 for a special preview and made its official debut on March 1, 2018. NBC released the first three episodes on NBCUniversal streaming platforms after the February 1 broadcast premiere for early viewing.

When disgraced Harvard philosophy scholar Jack Griffin (Glenn Howerton) loses out on his dream job to his rival Miles Leonard (Tom Bennett), he is forced to return to Toledo, Ohio and work as a high-school Advanced Placement Biology teacher. As he comes crashing into Whitlock High School, Jack makes it absolutely clear he will not be teaching any biology. Realizing he has a room full of honor-roll students at his disposal, Jack decides to use them for his own benefit: getting revenge on Miles. Eager to prove that he is still king of the castle, Principal Durbin (Patton Oswalt) struggles to control the force of nature that is Jack Griffin.

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