Podcasts like The Skeptics' Guide 5X5

The Skeptics' Guide to the Universe (SGU) is a weekly podcast hosted by Steven Novella, MD, along with a panel of "skeptical rogues." It is named to evoke The Hitchhiker's Guide to the Galaxy and is the official podcast of the New England Skeptical Society. The show features discussions of recent scientific developments in layman's terms, and interviews authors, people in the area of science, and other famous skeptics. The show also includes discussions of myths, conspiracy theories, pseudoscience, the paranormal, and many general forms of superstition, from the point of view of scientific skepticism.

The original lineup of the podcast consisted of Steven Novella, Evan Bernstein, Perry DeAngelis, Robert "Bob" Novella and Jay Novella. Rebecca Watson joined in March 2006. DeAngelis died in 2007 shortly before his 44th birthday. Watson departed the show at the end of 2014, and Cara Santa Maria joined the cast in July 2015.